It has long been known that female and male germ cells can be isolated from fetal gonads and coaxed, in vitro, to enter meiosis—the hallmark of gametogenesis (Handel et al., 2014). However, progression through meiosis could not be faithfully replicated outside the gonad. It seemed almost inconceivable that germ cells could acquire the morphological and molecular features of mature germ cells without also having completed meiosis. Thus, the idea took hold that gametogenesis in vivo is such a complex process that it could not possibly be completed correctly in vitro—a seemingly insurmountable obstacle. Had this idea held sway over experimental science, we most probably would not have written this editorial to promote this call for manuscripts.