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Free online access to recent Mutagenesis topical issues on the comet assay, targeted therapies in oncology, and Pig-a mutation assay.

Pig-a mutation assay
Guest Editors: Robert Heflich, Stephen Dertinger, and Vasily Dobrovolsky

The Pig-a assay has shown promise as a regulatory assay for evaluating in vivo gene mutation. A recent International Workshop on Genotoxicity Testing workgroup discussed the state of the assay and identified several knowledge gaps in assay development. This Mutagenesis Special Topic includes a collection of reports that addresses some of these knowledge gaps, including identifying the mutations responsible for the Pig-a mutant phenotype, the effect of sex on the response, probing the robustness of the assay and expanding the number of agents tested in the assay, especially agents expected to yield negative responses.

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Targeted therapies in oncology: challenges and perspectives for patients
Guest Editor: David Cox

The [Les Entretiens Jacques Cartier Symposium 4] colloquium… focused on methods of development and application of targeted therapies from a basic and clinical science aspect. These presentations, touching on aspects from fundamental science to bioinformatics to transferring advances to patients, involved researchers from both Europe and North America. A subset of these presentations, summarised here, showcase the potential for further improving our capacity to cure cancer.

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The Comet Assay
Guest Editor: Andrew Collins

Over the past 30 years, the comet assay has proved its usefulness and versatility in human biomonitoring, ecogenotoxicology, genotoxicity testing and basic research into the mechanisms of DNA damage and repair. In this special issue, we present some novel applications and developments, highlight some areas in which the assay’s potential has still to be fully realised, examine some unresolved practical issues, and give examples of application of the assay to studies of human and environmental health.

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Mutagenesis publishes papers on the physical, chemical and biological agents capable of producing genetic change in living organisms. The journal publishes manuscripts in a variety of different types:

• Original research articles
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• Meeting reports
• Letters to the Editors
• Papers on guidelines for mutagenicity testing of environmental agents
• Meta-analyses

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