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Journal Article
ACCEPTED MANUSCRIPT
A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma Get access
Mutagenesis, geae012, https://doi.org/10.1093/mutage/geae012
Published: 12 April 2024
Journal Article
ACCEPTED MANUSCRIPT
Commentary: Special Issue - Current Understanding of Colorectal and Pancreatic Cancers
Mutagenesis, geae009, https://doi.org/10.1093/mutage/geae009
Published: 29 March 2024
Journal Article
Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition
Mutagenesis, geae011, https://doi.org/10.1093/mutage/geae011
Published: 23 March 2024
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Inhibition of CYP1A1 (ethoxyresorufin-O-deethylase activity) (3A) ...
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Mutagenesis
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Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition
Published: 23 March 2024
Figure 3.
Inhibition of CYP1A1 (ethoxyresorufin- O -deethylase activity) (3A) and CYP1A2 (methoxyresorufin- O -demethylase activity) (3B) in rat liver microsomes by safrole. IC50 values were calculated by linear regression as described in the “Materials and methods” section.
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Inhibition of CYP1A1 (ethoxyresorufin-O-deethylase activity) (2A) ...
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Mutagenesis
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Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition
Published: 23 March 2024
Figure 2.
Inhibition of CYP1A1 (ethoxyresorufin- O -deethylase activity) (2A) and CYP1A2 (methoxyresorufin- O -demethylase activity) (2B) in rat liver microsomes by Piper auritum ethanolic extract. IC50 values were calculated by linear regression as described in the “Materials and methods” section.
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Antimutagenicity of Piper auritum Kunth extract against MeIQx in a...
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Mutagenesis
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Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition
Published: 23 March 2024
Figure 1.
Antimutagenicity of Piper auritum Kunth extract against MeIQx in a coincubation experiment in S. typhimurium TA98 strain in the presence of metabolic activation. ( − ) not added; (+) added before preincubation; ( ++ ) added after 20 min. coincubation at 37°C. Similar letters above each column me
Journal Article
Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices
Mutagenesis, Volume 39, Issue 3, May 2024, Pages 205–217, https://doi.org/10.1093/mutage/geae010
Published: 19 March 2024
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Buffy coat CBPI and frequency of micronuclei (percentage of binucleated cel...
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Mutagenesis
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Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices
Published: 19 March 2024
Figure 2.
Buffy coat CBPI and frequency of micronuclei (percentage of binucleated cells containing micronuclei (%Mn/BN)) determined by the in vitro CBMN assay following 1 cell cycle exposure to Au 5nm , Au 30nm , SiO 2 , and CeO 2 ENPs (A, B, C, and D, respectively). Positive controls used were Mitomycin C
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Whole blood CBPI and frequency of micronuclei (percentage of binucleated ce...
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Mutagenesis
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Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices
Published: 19 March 2024
Figure 3.
Whole blood CBPI and frequency of micronuclei (percentage of binucleated cells containing micronuclei (%Mn/BN)) determined by the in vitro CBMN assay following 1 cell cycle exposure to Au 5nm , Au 30nm , and BaSO 4 ENPs (A, B, and C, respectively). Positive controls used were Mitomycin C (MMC) at
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V79 CBPI and frequency of micronuclei (percentage of binucleated cells cont...
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Mutagenesis
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Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices
Published: 19 March 2024
Figure 5.
V79 CBPI and frequency of micronuclei (percentage of binucleated cells containing micronuclei (%Mn/BN)) determined by the in vitro CBMN assay following 1 cell cycle exposure to Au 5nm , Au 30nm , SiO 2 , BaSO 4 , and CeO 2 ENPs (A, B, C, D, and E, respectively). Positive controls used were ethyl
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V79 CBPI and frequency of micronuclei (percentage of binucleated cells cont...
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Mutagenesis
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Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices
Published: 19 March 2024
Figure 4.
V79 CBPI and frequency of micronuclei (percentage of binucleated cells containing micronuclei (%Mn/BN)) determined by the in vitro CBMN assay following 1 cell cycle exposure to Au 5nm , Au 30nm , and SiO 2 ENPs (A, B, and C, respectively). Positive controls used were ethyl methanesulfonate (EMS)
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TK6 and HepG2 cell viability and mutagenicity (percentage of binucleated ce...
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Mutagenesis
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Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices
Published: 19 March 2024
Figure 1.
TK6 and HepG2 cell viability and mutagenicity (percentage of binucleated cells containing micronuclei (%Mn/BN)) determined by the in vitro CBMN assay following exposure to Au 5nm , Au 30nm , and SiO 2 (TK6; A, B, C, respectively and HepG2; D, E, F). Positive controls: Mitomycin C (MMC) at 0.01 µg
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Summary of the molecular (blue text) and cellular (black text) endpoints us...
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Mutagenesis
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An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens
Published: 12 March 2024
Figure 1.
Summary of the molecular (blue text) and cellular (black text) endpoints used for the in vitro multiple-endpoint assay, and relationships between these endpoints. Arrows represent the series of events leading to gene upregulation (i.e. micronucleus induction leads to p53 accumulation, resulting in
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Summary of the overall scores for test chemicals based on ISC and number of...
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Mutagenesis
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An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens
Published: 12 March 2024
Figure 4.
Summary of the overall scores for test chemicals based on ISC and number of endpoints changed. Chemicals are coloured according to sub-category; gold = GC, brown = NGC, orange = misleading in vitro negative; grey = toxic NC, blue = misleading in vitro positive. Chemicals with a 0 score and there
Journal Article
Effects of aflatoxin and fumonisin on gene expression of growth factors and inflammation-related genes in a human hepatocyte cell line
Mutagenesis, Volume 39, Issue 3, May 2024, Pages 181–195, https://doi.org/10.1093/mutage/geae005
Published: 12 March 2024
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(A) Combined treatment of AFB1 and FB1 on HHL-16 cell...
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Mutagenesis
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Effects of aflatoxin and fumonisin on gene expression of growth factors and inflammation-related genes in a human hepatocyte cell line
Published: 12 March 2024
Figure 2.
(A) Combined treatment of AFB 1 and FB 1 on HHL-16 cells for 24 and 48 h. Control: untreated cells; D: DMSO treatment; P: PBS treatment; A: AFB 1 treatment; F: FB 1 treatment; PBS and DMSO treatment were normalized against control groups. Combined treatments were normalized against corresponding
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Gene expression of cytochrome P450 (CYP) enzymes in HHL-16 cells exposed to...
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Mutagenesis
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Effects of aflatoxin and fumonisin on gene expression of growth factors and inflammation-related genes in a human hepatocyte cell line
Published: 12 March 2024
Figure 3.
Gene expression of cytochrome P450 (CYP) enzymes in HHL-16 cells exposed to aflatoxin for 24 h. Control: untreated cells; D: DMSO treatment; A: aflatoxin treatment. ACTB : Beta-actine, a reference gene used for the normalization to CYP1A2 (A), CYP3A4 (B) and CYP3A5 (C). A significant increase
Journal Article
An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens
Mutagenesis, Volume 39, Issue 2, April 2024, Pages 69–77, https://doi.org/10.1093/mutage/geae004
Published: 12 March 2024
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Single AFB1 (A) or FB1 (B) treatment on HHL-16 cells ...
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Mutagenesis
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Effects of aflatoxin and fumonisin on gene expression of growth factors and inflammation-related genes in a human hepatocyte cell line
Published: 12 March 2024
Figure 1.
Single AFB 1 (A) or FB 1 (B) treatment on HHL-16 cells for 24 and 48 h. Control: untreated cells; D: DMSO treatments; A: AFB 1 treatments; P: PBS treatment; F: FB 1 treatment. DMSO and PBS treatments were normalized against the control group. AFB 1 treatments were normalized against correspondi
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Heat map of gene expression fold change of several selected genes in growth...
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Mutagenesis
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Effects of aflatoxin and fumonisin on gene expression of growth factors and inflammation-related genes in a human hepatocyte cell line
Published: 12 March 2024
Figure 4.
Heat map of gene expression fold change of several selected genes in growth factors pathway in HHL-16 cells exposed to single AFB 1 (10 µg/ml) or single FB 1 (50 µg/ml) for 24 h. A: AFB 1 treatment; F: FB 1 treatment. The colours represent the up-regulated (black) and down-regulated (white) gene
