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NAR Breakthrough Article

Tags: micro rna


Chemical Biology and Nucleic Acid Chemistry

Computational Biology

Tags: genes, mammals

Data Resources and Analyses

Gene Regulation, Chromatin and Epigenetics

Genome Integrity, Repair and Replication


Molecular Biology

Nucleic Acid Enzymes

Structural Biology

Synthetic Biology and Bioengineering


Methods Online

Tags: genes
  • Cover Image

    Cover Image

    issue cover
    Cover: RNA-induced movement of the RNA-binding domain of YxiN. Superposition of the final structural models for YxiN in the absence and presence of RNA on the helicase core (gray). Models were obtained from FRET-restrained modeling (left: back view, right: front view). The position of the RNA-binding domain (RRM) in the absence of RNA is shown in pale cyan, in the presence of RNA it is depicted in blue. The YxiN helicase core (dark gray: N-terminal RecA domain, RecA_N, light gray: C-terminal RecA domain, RecA_C) carrying the mutations S108C (red) and D262C (orange) in the open state is a homology model, generated using mjDEAD (PDB-ID 1hv8) as a template. The RRM containing cysteines at positions 429, 444, 464 and 472 (yellow), was modeled with the structure of the YxiN RRM (PDB-ID 2goc) as template. RNA binding to the YxiN RRM causes a large movement of the RRM from a position close to RecA_C of the helicase core towards RecA_N.
    For more information see article by Samatanga, B. et al., pages 1994–2006 in this issue.
  • Front Matter
  • Table of Contents
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