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NAR Breakthrough Article

Tags: micro rna

SURVEY AND SUMMARY

Chemical Biology and Nucleic Acid Chemistry

Computational Biology

Tags: genes, mammals

Data Resources and Analyses

Gene Regulation, Chromatin and Epigenetics

Genome Integrity, Repair and Replication

Genomics

Molecular Biology

Nucleic Acid Enzymes

Structural Biology

Synthetic Biology and Bioengineering

Erratum

Methods Online

Tags: genes
  • Cover Image

    Cover Image

    issue cover
    Cover: RNA-induced movement of the RNA-binding domain of YxiN. Superposition of the final structural models for YxiN in the absence and presence of RNA on the helicase core (gray). Models were obtained from FRET-restrained modeling (left: back view, right: front view). The position of the RNA-binding domain (RRM) in the absence of RNA is shown in pale cyan, in the presence of RNA it is depicted in blue. The YxiN helicase core (dark gray: N-terminal RecA domain, RecA_N, light gray: C-terminal RecA domain, RecA_C) carrying the mutations S108C (red) and D262C (orange) in the open state is a homology model, generated using mjDEAD (PDB-ID 1hv8) as a template. The RRM containing cysteines at positions 429, 444, 464 and 472 (yellow), was modeled with the structure of the YxiN RRM (PDB-ID 2goc) as template. RNA binding to the YxiN RRM causes a large movement of the RRM from a position close to RecA_C of the helicase core towards RecA_N.
    For more information see article by Samatanga, B. et al., pages 1994–2006 in this issue.
  • Front Matter
  • Table of Contents
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