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Hetero-expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity

Katherine L. Seley-Radtke

¹

University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA, ²Engelhardt Institute of Molecular Biology RAS, Moscow, Russia and ³Georgetown University Medical Center, 3900 Reservoir Road, Medical-Dental Building SW319, Washington, DC 20057, USA.

*

*Corresponding author. E-mail: kseley@umbc.edu.

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Katherine L. Seley-Radtke

Zhibo Zhang

¹

University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA, ²Engelhardt Institute of Molecular Biology RAS, Moscow, Russia and ³Georgetown University Medical Center, 3900 Reservoir Road, Medical-Dental Building SW319, Washington, DC 20057, USA.

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Zhibo Zhang

Orrette R. Wauchope

¹

University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA, ²Engelhardt Institute of Molecular Biology RAS, Moscow, Russia and ³Georgetown University Medical Center, 3900 Reservoir Road, Medical-Dental Building SW319, Washington, DC 20057, USA.

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Orrette R. Wauchope

Sarah C. Zimmermann

¹

University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA, ²Engelhardt Institute of Molecular Biology RAS, Moscow, Russia and ³Georgetown University Medical Center, 3900 Reservoir Road, Medical-Dental Building SW319, Washington, DC 20057, USA.

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Sarah C. Zimmermann

Alexander Ivanov

¹

University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA, ²Engelhardt Institute of Molecular Biology RAS, Moscow, Russia and ³Georgetown University Medical Center, 3900 Reservoir Road, Medical-Dental Building SW319, Washington, DC 20057, USA.

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Alexander Ivanov

Brent Korba

¹

University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA, ²Engelhardt Institute of Molecular Biology RAS, Moscow, Russia and ³Georgetown University Medical Center, 3900 Reservoir Road, Medical-Dental Building SW319, Washington, DC 20057, USA.

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Brent Korba

Nucleic Acids Symposium Series, Volume 52, Issue 1, 1 September 2008, Pages 635–636, https://doi.org/10.1093/nass/nrn321

Published:

01 September 2008

Abstract

Several thieno-expanded purine nucleoside analogues were synthesized for use as tools in ongoing investigations into nucleic acid structure and function in our laboratories. The inclusion of the thiophene ring system in the nucleoside endows the purine scaffold with advantages not previously available in other reported expanded purines. The synthesis and preliminary biological studies are reported herein.

© 2008 Oxford University Press

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