The clinical implication of monoclonal gammopathies: monoclonal gammopathy of undetermined significance and monoclonal gammopathy of renal significance
Batko and colleagues review the last definitions and treatment strategies of monoclonal gammopathies, a fast evolving field with important renal consequences. From B cells defects to tissue accumulation of abnormal proteins, these gammopathies are usually sensitive to chemotherapy, immunomodulation and monoclonal antibodies.
Diagnosis and management of asymptomatic bacteriuria in kidney transplant recipients: a survey of current practice in Europe
Asymptomatic bacteriuria is frequent in kidney transplant recipients (KTRs). We conducted a European survey to explore current practice related to the diagnosis and management of asymptomatic bacteriuria in adult KTRs.
Genetics of membranous nephropathy
Here we discuss the genetic studies that have proven the association of human leucocyte antigen class II and PLA2R1 variants and disease in MN. The common variants in PLA2R1 form a haplotype that is associated with disease incidence.
Elevated potassium levels in patients with chronic kidney disease: occurrence, risk factors and clinical outcomes—a Danish population-based cohort study
More than one in four CKD patients develops HK. Patients with severe CKD, diabetes, heart failure or use of spironolactone are at high risk. HK is associated with severe clinical outcomes.
Predicition models for delayed graft function: external validation on The Dutch Prospective Renal Transplantation Registry
With the use of data from the prospectively collected, nation-wide renal transplantation registry of The Netherlands, we performed external validation of four algorithms according to a novel framework as proposed by Debray et al.
Aetiology and management of acute kidney injury in multiple myeloma
Acute kidney injury (AKI) is very common in patients with multiple myeloma (MM). In some series, survival is reduced to <1 year in MM patients with AKI who do not recover renal function, and moreover the reversibility of MM-associated AKI is an important predictor of patient survival .
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