In this issue of Nephrology Dialysis Transplantation, Xia et al. report the results of a meta-analysis assessing the relation between smoking and chronic kidney disease (CKD) [1]. Their findings are based on 15 prospective cohorts including a total of more than 65 000 incident CKD patients. The summary relative risks for incident CKD and end-stage renal disease were 1.27 [95% confidence interval (95% CI), 1.19–1.35] and 1.51 (95% CI, 1.24–1.84), respectively, for ever-smokers, increasing to even 1.34 (95% CI, 1.23–1.47) and 1.91 (95% CI, 1.39–2.64) for current smokers. Remarkably, there was no association between smoking and proteinuria. Although these observations might appear to be confirmatory in nature, they highlight two important questions. One pertains to the biological rationale of the link between smoking and kidney disease, and what we can...

Article PDF first page preview

Article PDF first page preview
Article PDF first page preview
You do not currently have access to this article.

Comments

0 Comments