SP448
Role of Acute-phase Proteins (Orsomucoid 2 and hs-CRP) in Lean Type 2 Diabetic Patients with and without Subclinical Atherosclerosis

INTRODUCTION: Background: Type 2 Diabetes Mellitus (T2DM), is a global public health crisis that threatens the economies of all nations, particularly developing countries. Cardiovascular complications are the main cause of mortality in T2DM patients. Objective: The aim of this study is to explore the role of acute-phase proteins (Orsomucoid 2 and hs-CRP) as predictors for subclinical atherosclerosis and their relation with dyslipidaemia and Carotid intima media thicknes (CIMT) in lean T2DM patients.

METHODS: 50 diabetic normal weight patients (22 males and 28 females) were recruited from internal medicine department, AL-Zahraa hospital and divided into two groups: Group 1; twenty five type 2 diabetics with increased CIMT (≥ 0.9 mm) and Group 2; twenty five diabetic patients with normal CIMT (<0.9 mm). All the participants were subjected to full medical history, full clinical examination, and routine Laboratory investigations: Serum fasting glucose, urea, creatinine, uric acid, potassium, calcium, phosphorous, bilirubin, ALT, AST, albumin, complete lipid profile, hs-CRP and Orsomucoid 2 (ORM2) assay. Electrocardiogram (ECG), Echocardiography and B-mode ultrasonography of left and right carotid arteries were also assessed.

RESULTS: Serum orsomucoid 2 and hs-crp were significantly higher in group 1 compared to group 2 at (p≤0.001). Serum orosomucoid 2 at cut off 11.05 ng/L could discriminate patients with and without subclinical atherosclerosis. There was Positive correlation between serum orsomucoid level, hs-CRP and each of CIMT, LDL-C, and TG while negative correlation was found with HDL-C. Mean CIMT presented positive correlation with total cholesterol level, triglycerides and low-density lipoprotein.

CONCLUSIONS: Our findings suggest that orsomucoid 2 and hs-CRP could be used effectively as biomarkers for subclinical atherosclerosis in lean T2DM patients.