Revascularization Surgery in Moyamoya Disease Improves Clinical Disability and Reduces the Incidence of New Transient Ischemic Attack or Stroke 815

Moyamoya disease is characterized by the narrowing of the supraclinoid internal carotid arteries and their major branches, accompanied by the development of a cloud of collateral “moyamoya” vasculature. We present a consecutive series of moyamoya patients treated at Stanford University by the senior author (GKS) in the past 15 years. We evaluated the clinical outcome using the modified Rankin scale. Furthermore, we analyzed the effectiveness of revascularization to reduce the occurrence of transient ischemic attack (TIA) in the subgroup of patients presenting with TIA.

The clinical records for 173 patients undergoing 300 surgeries for moyamoya disease at Stanford University Medical Center between 1991 and 2006 were retrospectively reviewed.

There were 117 women and 56 men; the mean age at surgery was 29 years. We performed 242 direct and 58 indirect revascularization procedures. The mean follow-up time was 5.1 years (median, 3 yr)....