Several studies have indicated that omega-3 polyunsaturated fatty acids in fish oil have protective effects on cardiovascular disease by reducing vascular endothelial inflammation in atherosclerosis. In a recent study, supplementation of patients with fish oil following coronary angioplasty elevated levels of lipid peroxides and two adhesion molecules in plasma suggesting a proinflammatory action of fish oil. However, decreases in several plasma markers of endothelial hemostatic activity indicated a healthier and better vasculature associated with fish oil supplementation.

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