cover illustration Image from the paper by Nam et al. which shows Fv 1F8 (cartoon, cyan) binds to MMP-14 reaction cleft vicinity (electrostatic potential surface model, PDB 1BQQ) through direct interaction between the grafted Peptide G motif (yellow) and MMP-14 active site. The catalytic Zn2+ (magenta) of MMP-14 locates at the bottom of its reaction pocket. Residues Pro259 and Phe260 (sticks, green) form the S1' MMP-specific substrate binding pocket.
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