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Editors

SENIOR EDITORS

Alan Fersht

UK

Valerie Daggett

USA

CONSULTING EDITOR

Greg Winter
UK

METHODS EDITOR

Arne Skerra
Germany

EDITOR OF THE ANNUAL ANTIBODY ISSUE

James S. Huston
USA

EDITORIAL BOARD

Mikael Akke
Sweden
Protein dynamics; NMR spectroscopy; ligand binding


P. Balaram
India
Protein design; de novo peptide design; protein folding; analysis of motifs; disulfide engineering


Doug Barrick
USA
Repeat proteins; protein folding; consensus sequences; protein-protein interactions; statistical thermodynamics; allostery


Hagan Bayley
UK
Biosensors; biomolecular materials [fibers, elastomers, adhesives etc.];chemical modification of proteins; membrane proteins; photochemistry; single molecule biology


Richard Begent
UK


Albert Berghuis
Canada
Structural Biology; structural bioinformatics; computational chemistry; enzyme mechanism; enzyme evolution


Alan Berry
UK
Directed evolution; mechanistic enzymology; aldolases; enzyme engineering


Richard Bonneau
USA
Protein Structure Prediction; Protein Design; Peptidomimetic & Bioinspired Design


Alexandre Bonvin
USA
Biomolecular Interactions; Biomolecular Docking; Structure & Dynamics; Biomolecular Modelling; NMR Spectroscopy; Computational Structural Biology


Andrew Bradbury
USA
Phage display; selection systems; antibodies; fluorescent proteins; GFP; cre/lox recombination


Dennis Burton
USA
Antibodies; antibody engineering; virus glycoproteins; HIV; prion proteins


Silvia Cavagnero
USA
Protein folding; molecular chaperones; effect of cellular environment on biophysical phenomena; biological themodynamics and kinetics; NMR spectroscopy; fluorescence spectroscopy


Avi Chakrabartty
Canada
Protein Misfolding; Protein Aggregation; Neurodegenerative Disease; Proteomics; multi-photon microscopy; immunological approaches to protein misfolding disease


Ashutosh Chilkoti
USA
Protein based polymers; stimuli responsive polypeptides; protein-polymer conjugates


Fabrizio Chiti
Italy
Protein misfolding; protein aggregation; protein folding; amyloid fibrils; mechanisms of amyloid formation; protein deposition diseases; amyloid diseases


Daniel Christ
Australia


Jane Clarke
UK
Protein folding; protein stability; protein dynamics; force spectroscopy; AFM; protein elasticity; single molecule studies


Marius Clore
USA
NMR spectroscopy; structural biology; protein-protein interactions; protein-nucleic acid interactions; transcriptionfactors; signal transduction; computational chemistry; structure determination methods; structure prediction


Fred Cohen
USA
Protein misfolding; prion diseases; heteropolymer design; protein modeling


Matt Cordes
USA
Protein folding; protein evolution ; nuclear magnetic resonance ; conformational switching


Miroslaw Cygler
Canada
Protein structure; enzymatic mechanism; glycosaminoglycan processing enzymes; proteases and esterases; structural genomics


Michael Deem
USA
Statistical mechanics; protein evolution; original antigenic sin


William DeGrado
USA
Protein design; bioinorganic chemistry; protein folding


Bauke Dijkstra
Netherlands
Protein structure; enzyme mechanisms; protein engineering; crystallography; biophysical techniques


Christopher Dobson
UK


William Eaton
USA
Protein dynamics, folding and self-assembly; sickle cell disease


David Eisenberg
USA
Amyloid; domain swapping; prion structure; protein interations; functional networks


Edward Eisenstein
USA


Jacques Fastrez
Belgium
Directed evolution; selection for catalytic activity; phage display; proteases; lactamases and peptidases


Angelo Fontana
Italy
Protein folding; proteolysis; biospectroscopy; protein chemistry ; mass spectrometry


Assaf Friedler
Israel
peptides; peptide engineering; protein-protein interactions; biophysics; pharmacological chaperones; medicinal chemistry; HIV-1 proteins; cancer


Stefano Gianni
Italy
Protein folding; structural biology; protein-protein interaction; biophysics; kinetics


Lisa M. Gloss
USA
Oligomeric protein folding; histone dynamics; nucleosome and chromatin assembly; enzyme kinetics


Adrian Goldman
Finland
Protein structure; x-ray crystallography; enzyme modification; protein evolution


Richard Goldstein
UK
Protein evolution; protein bioinformatics


Angela Gronenborn
USA
NMR spectroscopy; protein structure and dynamics; folding and assembly; protein interactions; molecular recognition and signalling


Bernd Gutte
Switzerland
De novo design of functional peptides; protein folding; retro-proteins; phage display of peptide libraries


Kathleen Hall
USA
Protein Dynamics; NMR; RNA; Protein Interactions; Thermodynamics; Fluorescence


Torleif Härd
Sweden
Protein structure; protein stability; disulfide engineering; protein aggregation; amyloid; molecular recognition; NMR spectroscopy


Don Hilvert
Switzerland


Florian Hollfelder
UK
Enzyme mechanism; microfluidic technologies for directed enzyme evolution & enzyme discovery; chemical biology; enzyme models; physical-organic chemistry; organic reaction mechanism


Phil Holliger
UK
Directed evolution; repertoire selection; polymerases; replication; nucleotide chemistry


Hennie Hoogenboom
Netherlands


Amnon Horovitz
Israel
Chaperonins; allostery; mutant cycles; protein folding


Arthur Horwich
USA
Molecular chaperones; chaperonins; GroEL; folding in vivo; amyloids; TTR


James Huston
USA
Antibody engineering, recombinant fusion proteins and linkers, engineered bispecifics, immunotargeting, antibody therapeutic and imaging agents, intracellular antibody therapy.


Laura Itzhaki
UK
Protein Folding; Protein Engineering; Protein Stability


Leo James
UK
Immunology; structural biology/x-ray crystallography; kinetics; biophysics; protein-protein recognition


Dick Janssen
Netherlands
Hydrolases; enzyme kinetics; biocatalysis; dehalogenases


Laurent Jespers
UK
Phage display; antibody engineering; molecular evolution; domain antibody


Martin Karplus
USA


Jeff Kelly
USA


Thomas Kiefhaber
Germany
Protein folding; protein stability; reaction kinetics; protein dynamics


Kent Kirshenbaum
USA
Biomimetic chemistry; non-natural amino acids; alloproteins; foldamers; peptoids; bioconjugation; multivalency


Shohei Koide
USA
Protein Engineering; Antibody; Scaffold; Phage Display


Brian Kuhlman
USA


Andreas Kungl
Austria
Protein engineering; fluorescence; circular dichroism; microcalorimetry; proteomics; molecular dynamics; chemokines


Robin Leatherbarrow
UK
Peptide chemistry; peptide synthesis; protease; protease inhibitor; protein; NMR; enzyme kinetics; enzyme inhibition; molecular interactions


Zan Luthey-Schulten
USA


Jianpeng Ma
USA
Structural Biology; Protein Structure Modelling


George Makhatadze
USA


Bengt Mannervik
Sweden
Glutathione; combinatorial protein chemistry; directed evolution; phage display; protein redesign


James Marks
USA


Susan Marqusee
USA


Andreas Matouschek
USA
Protein folding and unfolding; protein degradation; ATP-dependent proteases; protein translocation across membranes; mechanism of protein machines


Brian Matthews
USA
Protein crystallography; protein stability; protein design.


C. Robert Matthews
USA


Stephen Mayo
USA


Liz Meiering
Canada
Protein folding; protein stability; protein misfolding and aggregation


Andrew Miranker
USA
Protein folding; spectroscopy; amyloid; protein-protein interactions; complex assembly


Kosuke Morikawa
Japan
Protein crystallography; DNA binding protein; ligand receptor interaction


Regina Murphy
USA
Protein/Peptide misfolding and aggregation; kinetics of amyloidogenesis; light scattering


Haruki Nakamura
Japan
Structural bioinformatics; protein and proteome databases; structural proteomics; molecular simulation; protein folding


Dario Neri
Switzerland
Therapeutic antibodies; protein libraries and selection methodologies; chelate effect and high-affinity binding; protein-based in vivo targeting, with special emphasis on angiogenesis-related diseases


Feng Ni
Canada
Polypeptide design; signaling protein interactions; binding allostery; instrinsically-unstructured proteins (IUPs); NMR; blood coagulation and antithrombotics


Ruth Nussinov
USA
Protein structure, protein-protein interactions, allostery, amyloids, Ras Protein


Robin Offord
Switzerland
Chemically synthesized proteins; semisynthetic proteins and peptides; chemokines; HIV receptor antagonists


Mikael Oliveberg
Sweden


Karyn O’Neil
USA
Antibody engineering; binding domains; bispecifics; targeted delivery; in vitro selection; biotherapeutics


Christine Orengo
UK
Protein family classification and analysis, structural genomics


Jane Osbourn
UK
Antibody engineering; phage display; ribosome display; selection technology


Hartmut Oschkinat
Germany


Daniel Otzen
Denmark
Protein folding kinetics; protein stability; membrane protein biophysics; protein fibrillation; surfactants


Rohit V. Pappu
USA
Protein aggregation; computational biophysics / molecular simulations; theory; intrinsically disordered proteins; protein design


Evamaria Petersen
Denmark
Protein engineering; molecular directed evolution; lipase; lipid binding proteins


Andreas Plueckthun
Switzerland
Directed evolution; display and selection technologies; ligand binding; protein stability; antibody engineering; protein design


Flemming Poulsen
Denmark


Ron Raines
USA
Chemical biology; protein chemistry; enzymology


Daniel Raleigh
USA
Amyloid formation and protein aggregation; protein design; protein stability and thermodynamics; NMR


Anthony Rees
Sweden
Antibody modeling; antibody mimetics; artificial receptors


Lynne Regan
USA
Protein design; folding; stability; helical proteins; protein-metal interactions; protein-protein interaction; protein-RNA interactions


Heinrich Roder
USA
Protein folding; kinetics; folding intermediates; rapid mixing; NMR; hydrogen exchange


Peter Roepstorff
Denmark
Mass spectrometry; proteomics; post translational modifications; protein interaction


Frederic Rousseau
Belgium
Protein folding and misfolding; Sequence determinants of protein aggregation; Biophysics; Structural bioinformatics


Steven Russell
USA
Virotherapy; gene therapy; virus display; targeting; membrane fusion


Andrej Sali
USA
Protein structure analysis and modeling; protein assembly analysis and modeling


Jeffery G. Saven
USA


Harold Scheraga
USA
Protein folding; physical chemistry; statistical mechanics; global optimization


Gideon Schreiber
Israel
Protein-protein interaction; binding kinetics; proteomics; protein design; interferon; cooperativity


Klaus Schulten
USA
Computational biology; membrane proteins; mechanical proteins; photosynthetic apparatus; nanosystem bioengineering


Joost Schymkowitz
Belgium
Protein folding and misfolding; Protein aggregation; Molecular Chaperones; Amyloid fibrils; Biophysics; Structural bioinformatics


Jamie Scott
Canada


Luis Serrano
Germany


P C Shaw
Hong Kong
Molecular biology & protein engineering; protein-protein interaction; ribsome inactivating protein; N-glycosidase; DNA methylase


Arne Skerra
Germany
Rational design; combinatorial selection; antibody engineering; binding proteins; protein crystallography


Stephen Sligar
USA
Self-Assembly; Lipoproteins


Dieter Soll
USA
Aminoacyl-tRNA synthetases; RNA modification enzymes; RNA; protein interactions


Tobin Sosnick
USA
Protein folding; RNA folding; kinetics; hydrogen exchange; small-angle scattering


Neil Stahl
USA


Michael Sternberg
UK
Bioinformatics; protein modelling


Robert Stroud
USA
Protein crystallography especially applied to membrane channels and receptors and to drug design aimed at therapeutically important targets


Joel Sussman
Israel
Protein crystallography; bioinformatics; neurobiology; intrinsically unfolded proteins; structural proteomics; halophilic/halotolerant proteins; acetylcholinesterase/butyrylcholinesterase


Lukas Tamm
USA


Dan Tawfik
Israel
Enzyme evolution; directed evolution; enzyme mechanisms; protein conformation; antibodies


David Thirumalai
USA
Computational and theoretical biophysics; protein folding; protein aggregation; chaperone-mediated folding; single molecule studies


Janet Thornton
UK
Computational biology; bioinformatics; structural biology; genomics


Bruce Tidor
USA
Computational biology; protein and ligand design; electrostatic interactions; molecular dynamics; protein-DNA interactions; systems biology


Peter Tieleman
Canada
Expertise terms: membrane proteins, protein modeling, biomolecular simulation, membrane biophysics


Jayant Udgaonkar
India


Mathias Uhlen
Sweden
Proteomics; combinatorial selection; affinity purification; expression profiling


Rebecca Wade
Germany
Computational biology; molecular recognition; molecular dynamics; protein and ligand design; molecular simulation


Sally Ward
USA


Jim Wells
USA


Rik Wierenga
Finland
Protein crystallography; protein engineering; TIM; CoA; enzymology


Tony Wilkinson
UK
Protein structure; enzyme mechanisms; protein engineering; crystallography; expression systems


Roger Williams
UK
Protein structure; signal transduction; protein/lipid interactions; phosphoinositide signalling


Stephen Withers
Canada
Enzyme mechanisms; glycosyl transfer; glycosidase; carbohydrates


Kambo Wong
Hong Kong
NMR; protein crystallography; protein stability; protein engineering


Dek Woolfson
UK
Structural studies of peptides and proteins; rational protein design; combinatorial design and selection; nanobiotechnology


Anna Wu
USA
Recombinant antibody fragments; antibody fusion proteins; molecular imaging; pharmacokinetics; bioconjugation of nanomaterials


Todd Yeates
USA
Protein structure and design; x-ray crystallography; symmetry and self-assembly; protein topology and knots, algorithms


Huan-Xiang Zhou
USA
Macromolecular crowding; intrinsically disordered proteins; peptide self-assembly; protein electrostatics; binding kinetics


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