Phloem Mobility of Xenobiotics: I. Mathematical Model Unifying the Weak Acid and Intermediate Permeability Theories

Abstract

A passive diffusion model has been developed which simultaneously accounts for the dependence of phloem mobility on permeability and acid dissociation. The model is consistent with the observation that the addition of an acid moiety to an otherwise phloem immobile compound may enhance that compound's ability to move in the phloem. However, acid trapping in the basic phloem is not the only enhancement factor. Acid functionalization also lowers the effective permeability usually towards its optimum value. The unified theory predicts that for a given acid dissociation constant there is an optimum permeability and conversely for a given permeability there is an optimum dissociation constant.