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Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens
Austen A Fisher and others
Dopamine release in the nucleus accumbens (NAc) plays a critical role in the motivation to perform actions that promote survival. However, the NAc dopamine response to innately threatening visual stimuli, such as predators descending from above, and the innate behaviors they promote has not been ...
Unraveling the causal influences of drought and crop production on groundwater levels across CONUS
Nitin K Singh and others
Groundwater depletion in agricultural-dominated regions is attributed to climate and irrigation withdrawals that support crop production. However, despite decades of effort, knowledge gaps remain in understanding the relative influence of drought and crop production on groundwater levels at the ...
Democratic backsliding damages favorable US image among the global public
Benjamin E Goldsmith and others
US democracy appears to have weakened during the 21st century. Scholars have raised concerns that this democratic backsliding will reduce favorable views of the United States among foreign citizens in other democracies. In turn, observers predict that the eroded global image of the United States ...
An inverse relationship between fitness and secretion efficiency in a gram-positive bacterium
Kamilla Wiull and others
Lactiplantibacillus plantarum and other lactic acid bacteria are emerging as promising candidates for mucosal delivery of surface-displayed antigens. However, producing secreted heterologous proteins and anchoring these using LPxTG-anchors can significantly reduce bacterial fitness. To understand ...
The priming phosphorylation of KaiC is activated by the release of its autokinase autoinhibition
Yoshihiko Furuike and others
KaiC, a cyanobacterial circadian clock protein with autokinase activity, catalyzes the dual phosphorylation of its own S431 and T432 residues in a circadian manner in the presence of KaiA and KaiB. Priming phosphorylation at T432 is a key step that promotes secondary phosphorylation at S431. ...
Self-sustained rhythmic behavior of Synechocystis PCC 6803 under continuous light conditions in the absence of light-dark entrainment
Lutz C Berwanger and others
Circadian clocks regulate biological activities, providing organisms with a fitness advantage under diurnal conditions by enabling anticipation and adaptation to recurring external changes. Three proteins, KaiA, KaiB, and KaiC, constitute the circadian clock in the cyanobacterial model ...
Enzymes helping enzymes: Oxaloacetate decarboxylase increases malate dehydrogenase's turnover number
Gadiel Saper and Henry Hess
The catalytic performance of enzymes is largely perceived to be a property of the enzyme itself, altered by environmental conditions such as temperature and pH. However, the maximal catalytic rates of enzymes differ up to hundred-fold between in vivo and in vitro measurements, suggesting that a ...
Air pollutions affect restaurant and foodservice industry in China
Xu Tian and others
This study examines the impact of air pollution on food away from home (FAFH) consumption in 52 cities across 20 provinces of China, focusing on expenditures for online food delivery (online FAFH) and dine-in restaurants (offline FAFH). Using unique daily aggregated city-level consumption data ...

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Shaping PNAS Nexus: Editor-in-Chief Yannis C. Yortsos

Listen to PNAS Nexus Editor-in-Chief Yannis C. Yortsos’ views on 

•    the interdisciplinary nature of modern research,

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•    the importance of peer review,

•    balancing technological advancement against potential consequences.

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As a fully open access journal, PNAS Nexus meets all major funder mandates. The journal is committed to high ethical standards and subscribes to the principles of the Committee on Publications Ethics (COPE). 

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