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Schizophrenia Bulletin
The flagship journal of the Schizophrenia Bulletin family. Reviews recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia, ranging from the molecular basis to social and cultural factors.
Journal

Schizophrenia Bulletin Open
Schizophrenia Bulletin Open is an online-only, open access journal new in 2020.
The journal publishes new knowledge ranging from the molecular basis to social and
cultural factors regarding the etiology and treatment of schizophrenia.
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Seed-to-voxel functional connectivity analysis of the MPFC. The first row i...
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Schizophrenia Bulletin
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Disturbed Functional Connectivity Between Anterior Default Mode and Sensory Processing Regions Is Linked to Peripheral Inflammatory Markers and Psychopathology in Schizophrenia
Published: 23 April 2025
Figure 2.
Seed-to-voxel functional connectivity analysis of the MPFC. The first row illustrates the definition of the seed. In the second row, the effect of IL-6 on functional connectivity is presented: a cluster of hypo-connectivity emerged in the right hemisphere encompassing the parietal operculum and audi
Journal Article
Disturbed Functional Connectivity Between Anterior Default Mode and Sensory Processing Regions Is Linked to Peripheral Inflammatory Markers and Psychopathology in Schizophrenia
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Emanuel Mlynek and others
Schizophrenia Bulletin, sbaf048, https://doi.org/10.1093/schbul/sbaf048
Published: 23 April 2025
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(A) ROI-to-ROI functional connectivity analysis assessed the association be...
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Schizophrenia Bulletin
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Disturbed Functional Connectivity Between Anterior Default Mode and Sensory Processing Regions Is Linked to Peripheral Inflammatory Markers and Psychopathology in Schizophrenia
Published: 23 April 2025
Figure 1.
(A) ROI-to-ROI functional connectivity analysis assessed the association between IL-6 (left) or CRP (right) and the connectivity between the MPFC and different regions related to somato- or viscerosensory processing. SMN = sensorimotor network; ant. = anterior; lat. = lateral; sup. = superior; PO =
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Structural and behavioral correlates of disturbed functional connectivity b...
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Schizophrenia Bulletin
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Disturbed Functional Connectivity Between Anterior Default Mode and Sensory Processing Regions Is Linked to Peripheral Inflammatory Markers and Psychopathology in Schizophrenia
Published: 23 April 2025
Figure 3.
Structural and behavioral correlates of disturbed functional connectivity between the medial prefrontal cortex (MPFC) and the right parietal opercular cortex (PO r). (A) Visualization of fibers tracked between the two seeds from a representative patient using probabilistic fiber tracking. (B) Scatte
Journal Article
Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia
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Feng-Yi Yang and others
Schizophrenia Bulletin, sbaf031, https://doi.org/10.1093/schbul/sbaf031
Published: 18 April 2025
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Effects of LIPUS stimulation on the expressions of 5-HT1AR and 5-HT2AR in t...
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Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia
Published: 18 April 2025
Figure 3.
Effects of LIPUS stimulation on the expressions of 5-HT1AR and 5-HT2AR in the medial prefrontal cortex (mPFC) of MK-801-treated rats. (A) Representative images showing 5-HT1AR-positive cells (first column) and NeuN-positive cells (second column) in the mPFC. Arrows point to cells co-labeled for 5-HT
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Behavioral effects of LIPUS stimulation on rats administered MK-801. (A) Im...
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Schizophrenia Bulletin
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Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia
Published: 18 April 2025
Figure 1.
Behavioral effects of LIPUS stimulation on rats administered MK-801. (A) Impact of LIPUS on MK-801-induced impairment in prepulse inhibition. (B) Sucrose preference of each group. (C) Schematic diagram of the social interaction test. Time spent on (D) sniffing, (E) following, (F) climbing, (G) avoid
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Effects of LIPUS stimulation on NMDAR1 subunits, GAD, and excitation/inhibi...
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Schizophrenia Bulletin
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Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia
Published: 18 April 2025
Figure 2.
Effects of LIPUS stimulation on NMDAR1 subunits, GAD, and excitation/inhibition (E/I) ratio of the mPFC of MK-801-treated rats. (A) Representative immunofluorescence images showing NMDARR1 subunit (first column), PV (second column), and DAPI (third column) labeling in the medial prefrontal cortex (m
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The impact of LIPUS stimulation on MK-801-induced c-Fos expression in TH-po...
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Schizophrenia Bulletin
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Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia
Published: 18 April 2025
Figure 4.
The impact of LIPUS stimulation on MK-801-induced c-Fos expression in TH-positive dopamine neurons in the VTA. (A) Representative images showing c-Fos-positive cells (first column) and TH-positive cells (second column), and DAPI (third column) staining in the VTA. The arrow indicates c-Fos- and TH-l
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The influence of LIPUS stimulation on gut microbiome composition in MK-801-...
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Schizophrenia Bulletin
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Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia
Published: 18 April 2025
Figure 5.
The influence of LIPUS stimulation on gut microbiome composition in MK-801-treated rats. (A) A Venn diagram was employed to evaluate the common and unique operational taxonomic units in the 4 groups. Bar plots of relative abundance show bacterial composition at the (B) phylum, (C) class, and (D) gen
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CONSORT flow chart shows disposition of 120 consented subjects, 68 randomiz...
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Pharmacologic Augmentation of Computerized Auditory Training in Chronic Psychosis: Preliminary Findings From a Single-Site, Double-Blind Study
Published: 14 April 2025
Figure 1.
CONSORT flow chart shows disposition of 120 consented subjects, 68 randomized subjects, and 50 study “completers.” Abbreviations: W = withdrew from study; E = excluded from study; tox = urine toxicology screen positive for methamphetamine (excluded after 3 rd consecutive weekly positive result; see
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“Ideal” PACT model is represented. A. Baseline values of outcome measure (T...
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Schizophrenia Bulletin
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Pharmacologic Augmentation of Computerized Auditory Training in Chronic Psychosis: Preliminary Findings From a Single-Site, Double-Blind Study
Published: 14 April 2025
Figure 2.
“Ideal” PACT model is represented. A. Baseline values of outcome measure (T 1 , open bar), expected reduction (improvement) in outcome measure resulting from 30 sessions (P30) of AT + PBO (lined bar), and the extra benefits of adding an effective “pro-learning” drug to 30 sessions of AT (solid bar).
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Outcome measures in PBO group, AMPH group, and MEM group subjects, measured...
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Schizophrenia Bulletin
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Pharmacologic Augmentation of Computerized Auditory Training in Chronic Psychosis: Preliminary Findings From a Single-Site, Double-Blind Study
Published: 14 April 2025
Figure 3.
Outcome measures in PBO group, AMPH group, and MEM group subjects, measured at T 1 , P10, P20, P30, and 12 weeks after completion of AT (“durability assessment” (DA)). Data shown reflects all subjects who completed at least T 1 and P10 testing (T1: n = 60; P10: n = 60; P20: n = 54; P30: n =
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Prediction Process Using KNIME Analytical Platform KNIME prediction proc...
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The Retinal Age Gap as a Marker of Accelerated Aging in the Early Course of Schizophrenia
Published: 14 April 2025
Figure 1.
Prediction Process Using KNIME Analytical Platform KNIME prediction process
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Moderation Effects of Change in Insight on Length of Stay and Number of Hos...
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Schizophrenia Bulletin
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Insight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care
Published: 14 April 2025
Figure 3.
Moderation Effects of Change in Insight on Length of Stay and Number of Hospitalizations.
Journal Article
Combining the Risk: The Poly-Environmental Risk Score and Psychotic Symptoms in Adolescents
Diandra C Bouter and others
Schizophrenia Bulletin, sbaf046, https://doi.org/10.1093/schbul/sbaf046
Published: 14 April 2025
Journal Article
Insight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care
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Hadar Hazan and others
Schizophrenia Bulletin, sbaf019, https://doi.org/10.1093/schbul/sbaf019
Published: 14 April 2025
Journal Article
The Retinal Age Gap as a Marker of Accelerated Aging in the Early Course of Schizophrenia
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Paweł Krukow and others
Schizophrenia Bulletin, sbaf038, https://doi.org/10.1093/schbul/sbaf038
Published: 14 April 2025