Phencyclidine/Schizophrenia: One View Toward the Past, The Other to the Future

Domino, Edward F.; Luby, Elliot D.

doi:10.1093/schbul/sbs011

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Phencyclidine/Schizophrenia: One View Toward the Past, The Other to the Future

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Abstract

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.

phencyclidine, drug model, drug of abuse

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Phencyclidine/Schizophrenia: One View Toward the Past, The Other to the Future

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Phencyclidine/Schizophrenia: One View Toward the Past, The Other to the Future

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