CAN INSIGHT LEAD TO REMISSION - FOR PATIENTS WITH SCHIZOPHRENIA?

Discussion: The result in the present study showed that patients with low function who overestimate their function have less or the same level of symptoms as patients in the two groups with ordinary functioning. In further studies it is important to investigate if this actually is a result of lower symptom level or if it is due to the impaired insight. This is important since the result in the present study mirror previous results where patients who overestimate a low function also, by clinicians, will be perceived as patients with a higher capacity and less difficulties. the associations between neighborhood characteristics, social factors (namely, perceived rejection and loneliness), social network, and paranoia. Methods: The current study will examine how paranoia correlates with neighborhood characteristics, loneliness, perceived rejection, and social network size in a transdiagnostic sample with psychosis. We will utilize the Neighborhood Environment Scale (Mujahid et al., 2007) to assess social cohesion, safety, violence, and activities with neighbors within participants’ residencies. We will use the Paranoid Thought Scales (Green et al., 2008) to assess paranoid ideation and the Adult Social Relationship Scales (Cyranowski et al., 2013) to assess perceived rejection and loneliness over the past month. In addition, we will use the Social Network Index (Cohen et al., 1997) to investigate the correlation between participants’ social network and paranoia, social rejection, and loneliness. Results: Preliminary results (N = 13) indicate a significant correlation between paranoia and perception of neighborhood social cohesion (r = -0.57, p < 0.05). In addition, loneliness (r = 0.60, p < 0.05) and perceived social rejection (r = 0.52, p < 0.05) were the largest correlates of par- anoia. We will conduct formal analyses with a larger N to further explore these and other associations. Discussion: data has been collected. Background: A disorganization factor was found by several factor-ana- lytic studies of schizophrenia symptoms. This factor does not appear to be affected by age, severity of other symptoms and chronicity of illness. A greater occipital sites. At the items level, only N5 showed the same negative correlation at occipital sites. MCCB neurocognitive composite score was associated with disorganization factor, and its constituent items P2 and N5. No significant correlation between Alpha1 SAmp and MCCB cognitive domains was observed. Discussion: Our findings illustrate the heterogeneity of disorganization dimension and a partial overlap with neurocognitive domains. ‘Difficulty in abstract thinking’ showed a unique association with Alpha1 activity, which is thought to be involved in the construction of conceptual maps. Furthermore, the observed association of Alpha1 with ‘Difficulty in abstract thinking’ suggests that some aspects of disorganization could be underpinned by the impairment of basic neurobiological functions that are only partially evaluated using MCCB. Background: Many studies have highlighted the similarity of the symp- toms between bipolar disorders and schizophrenia. Moreover, there are no pathognomonic symptoms that can differentiate these two disorders, and 9% of schizophrenia patients have experienced a manic syndrome in their lifetime. Insight about their symptoms and illness is very important fac- tor for the differential diagnosis and the management in schizophrenia. To examine the relationship among the insight, the psychotic and manic symp- toms, and clinical variables in patients with chronic schizophrenia. Methods: Seventy-four participants (male 44, female 30) with chronic schiz- ophrenia in community mental health facilities have been evaluated with the Scale to assess Unawareness of Mental Disorder (SUMD), the Mood Disorder Questionnaire (MDQ), and the Brief Psychiatric Rating Scale (BPRS). Results: The mean number of previous admission was 3.85. Their drug adherence was favorable (6.73 day/week). Mean CGI-S score was 3.8. Thirty-five percent of subject were MDQ positive (cutoff point = 7 or more). Among SUMD, “awareness of effect of medication” showed significant negative correlation (r = -0.33) with total MDQ score not with total BPRS score. The negative correlation was more obvious in participants with negative MDQ (total MDQ score 6 or less, r = -0.31). Several MDQ items (irritability, r = -0.25; decreased sleep, r = -0.27; thought racing, r = -0.28; and easy distractibility, r = -0.40) negatively correlated with “awareness of effect of medication”. In contrast, only one item (guilt feeling, r = -0.27) of BPRS revealed this correlation. Individual items in MDQ and BPRS rarely correlated with each other. Total MDQ score was not correlated with dura-tion of illness and medication adherence. Discussion: differentially only the total MDQ score. There was possible relationship between these manic symptoms and their insight. Identifying manic symptoms in schizophrenia would be considerable in clinical setting. ability the epi- sodes. their for in remission. has shown an remission status from approximately 30% to more than 50% after using standardized remission criteria for patients with schizophrenia This study aims to investigate the relationship between both insight of symptoms and illness insight with cross-sectional remission. study 289 111 were and men, with a mean of 47 years (19–83 years old). Using semi-structured interviews and evidence-based assessment scales Remission Scale - Symptom (RS-S) and Psychosis Evaluation Tool for Common use by Caregivers (PECC) the is collected. Cross tabu-lations were used to compare the distribution of the variables and the Pearson Chi-Square Tests for examine significant association. Results: of symptom: The results show the who are not in remission, 69.5% are to while are having insight of symptoms. When it comes to the patients within remission, have an insight of 41.0% are this sort of insight. The findings in the analysis with Chi-Square Tests examine independence indicated significant association between insight of symptoms and

Background: A disorganization factor was found by several factor-analytic studies of schizophrenia symptoms.This factor does not appear to be affected by age, severity of other symptoms and chronicity of illness.A greater severity of disorganization is associated with poor functioning.Despite the general similarity of different factorial model, there is no consensus about which symptoms have to be included in the disorganization factor.Using the Positive and Negative Syndrome Scale (PANSS), Conceptual disorganization' (P2), 'Difficulty in abstract thinking' (N5) and 'Poor attention' (G11) were core features of the disorganization factor.The overlap of these items with neurocognitive functions is still debated.However, the heterogeneity of this factor and its neurobiological basis should be further investigated.In the context of the multicenter study of the Italian Network for Research on Psychoses, the main aims of our study were to investigate electrophysiological and neurocognitive correlates of the disorganization factor, and to assess if each PANSS item, loading on the disorganization factor, could be underpinned by similar electrophysiological or cognitive alterations.Methods: Resting state EEGs were recorded for 5 minutes in 145 stabilized subjects with schizophrenia (SCZ) and 69 matched healthy controls (HC).The disorganization factor was evaluated using three PANSS items: P2, N5, and G11 (4).Neurocognitive functions were assessed using the MATRICS Consensus Cognitive Battery (MCCB).Spectral amplitude was quantified in nine frequency bands.All statistical analyses of the scalp multichannel spectral amplitude (SAmp) data were performed using RAGU software.Statistical comparisons between the SAmp maps of SCZ and HC were assessed by topographic analyses of variance (TANOVA).In SCZ, topographic analyses of covariance (TANCOVA) evaluated correlations between SAmp and disorganization, its constituent items and MCCB domains.Furthermore, Pearson's correlations were performed between disorganization and its constituent items and MCCB neurocognitive domains.Results: TANOVA, comparing the group SAmp maps revealed increased Delta, Theta, and Beta1 and decreased Alpha2 SAmp in SCZ.In the SCZ group, disorganization was significantly correlated to the Alpha1 SAmp.This relation was negative and most pronounced at occipital sites.At the items level, only N5 showed the same negative correlation at occipital sites.MCCB neurocognitive composite score was associated with disorganization factor, and its constituent items P2 and N5.No significant correlation between Alpha1 SAmp and MCCB cognitive domains was observed.Discussion: Our findings illustrate the heterogeneity of disorganization dimension and a partial overlap with neurocognitive domains.'Difficulty in abstract thinking' showed a unique association with Alpha1 activity, which is thought to be involved in the construction of conceptual maps.Furthermore, the observed association of Alpha1 with 'Difficulty in abstract thinking' suggests that some aspects of disorganization could be underpinned by the impairment of basic neurobiological functions that are only partially evaluated using MCCB.

F115. INSIGHT AND MANIC SYMPTOMS IN PATIENTS WITH CHRONIC SCHIZOPHRENIA IN THE KOREAN COMMUNITY
Duk-In Jon* ,1 , Bo-Hyun Yoon 2 , Sang-Yeol Lee 3 , Kwanghun Lee4 , Won-Myong Bahk5 , Beomwoo Nam 6 , Sung-Yong Park Background: Many studies have highlighted the similarity of the symptoms between bipolar disorders and schizophrenia.Moreover, there are no pathognomonic symptoms that can differentiate these two disorders, and 9% of schizophrenia patients have experienced a manic syndrome in their lifetime.Insight about their symptoms and illness is very important factor for the differential diagnosis and the management in schizophrenia.To examine the relationship among the insight, the psychotic and manic symptoms, and clinical variables in patients with chronic schizophrenia.Methods: Seventy-four participants (male 44, female 30) with chronic schizophrenia in community mental health facilities have been evaluated with the Scale to assess Unawareness of Mental Disorder (SUMD), the Mood Disorder Questionnaire (MDQ), and the Brief Psychiatric Rating Scale (BPRS).

Results:
The mean number of previous admission was 3.85.Their drug adherence was favorable (6.73 day/week).Mean CGI-S score was 3.8.Thirty-five percent of subject were MDQ positive (cutoff point = 7 or more).Among SUMD, "awareness of effect of medication" showed significant negative correlation (r = -0.33)with total MDQ score not with total BPRS score.The negative correlation was more obvious in participants with negative MDQ (total MDQ score 6 or less, r = -0.31).Several MDQ items (irritability, r = -0.25;decreased sleep, r = -0.27;thought racing, r = -0.28;and easy distractibility, r = -0.40)negatively correlated with "awareness of effect of medication".In contrast, only one item (guilt feeling, r = -0.27) of BPRS revealed this correlation.Individual items in MDQ and BPRS rarely correlated with each other.Total MDQ score was not correlated with duration of illness and medication adherence.Discussion: Manic symptoms were frequently detected even in schizophrenia as reported in previous studies.This made it difficult to differentially diagnose the disorder using only the total MDQ score.There was possible relationship between these manic symptoms and their insight.Identifying manic symptoms in schizophrenia would be considerable in clinical setting.

F116. CAN INSIGHT LEAD TO REMISSION -FOR PATIENTS WITH SCHIZOPHRENIA?
Maivor Olsson-Tall* ,1 , Fredrik Hjärthag 2 , Anna-Karin Olsson 1 , Madeleine Johansson 1 , Hawar Moradi 1 , Lars Helldin 1 1 NU Health Care Hospital; 2 Karlstad University Background: It is important to have extensive knowledge of the patients with schizophrenia, to provide the right support in outpatient care to create a good situation for the patient and prevent hospitalization.Lack of insight regarding the illness and symptoms might impair the patient's ability to understand the illness, the treatment and relapses into psychotic episodes.Symptomatic remission is a well-established goal for treatment.If the core-symptoms do not affect their functions and the status is stable for at least six months, the patient is in remission.Previous research has shown an increased remission status from approximately 30% to more than 50% after using standardized remission criteria for patients with schizophrenia in Sweden.This study aims to investigate the relationship between both insight of symptoms and illness insight with cross-sectional remission.Methods: This is a cross-sectional study and the participants consisted of totally 289 patients with schizophrenia diagnosis.Of the participants 111 were women and 178 were men, with a mean age of 47 years (19-83 years old).Using semi-structured interviews and evidence-based assessment scales Remission Scale -Symptom (RS-S) and Psychosis Evaluation Tool for Common use by Caregivers (PECC) the data is collected.Cross tabulations were used to compare the distribution of the variables and the Pearson Chi-Square Tests for examine significant association.
Results: Insight of symptom: The results show that from the patients who are not in remission, 69.5% are missing insight to symptoms, while 30.5% are having insight of symptoms.When it comes to the patients within remission, 59.0% have an insight of symptoms, while 41.0% are missing this sort of insight.The findings in the analysis with Chi-Square Tests examine independence indicated significant association between insight of symptoms and remission status (1, x2 = 22.17), p = <0,001, phi = -0.28.Insight of illness: During the analysis of insight of illness, the results show that from the patients who are in remission, 61.9% possess insight of illness, compared to 38.1% of the patients lacking insight of illness.
Concerning the insight of illness for the patients who are not in remission, 68.2% lack insight of illness, while 31.8%possess insight of illness.The Chi-Square Tests examine independence indicated significant association between insight of illness and remission status (1, x2 = 24.28),p = <0.001,phi = -0.29.Discussion: The results show that there is a relationship between insight of symptoms and illness with the cross-sectional symptomatic remission.However, the question is still open if remission is a consequence of insight or if the insight changes over time according to the activity of the illness.By following patients over time and monitoring the activity of symptoms including the state of remission and insight, it will probably be visualized if changes occur related to each other or independently.Also, whether the main focus for success is pharmaceutical treatment aiming for maximal symptom reduction or psychoeducational treatment to develop patients' ability to understand their illness.Finally, whether insight after being established is a state or a treatment phenomenon?Further research to explore this issue is needed.
As hypothesized, schizotypy, DASS, and internalized stigma were all positively associated.Internalized stigma could lead to symptoms of depression, anxiety and stress as well as schizotypy.It is possible that internalized stigma plays its own unique role in the onset of schyzotypy.This study is limited by the self-report and cross-sectional nature.Longitudinal studies are necessary to further assess causality in these variables.Screening for schizotypal personality traits when patients present for symptoms of depression and anxiety could be useful in early intervention Downloaded from https://academic.oup.com/schizophreniabulletin/article-abstract/44/suppl_1/S264/4957711 by guest on 26 July 2018