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3D spheroid MDFs promotes the regeneration of the transected sciatic nerves...
Published: 11 April 2025
Figure 4.
3D spheroid MDFs promotes the regeneration of the transected sciatic nerves. (A) Images of gross morphology, (B) H&E images, (C) Quantitative analysis of diameter ( n = 6), and (D) TEM images of regenerated rat sciatic nerve 6 weeks following injury in different treatment groups. (E) Images of
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3D spheroid culture upregulates the expression of Semaphorin7a through over...
Published: 11 April 2025
Figure 6.
3D spheroid culture upregulates the expression of Semaphorin7a through overexpressing of ID3. Immunocytochemistry staining and the corresponding fluorescence intensity quantification (A, B) ( n = 8), RT-PCR (C) ( n = 3), and western blotting (D) for Semaphorin7a in monolayer MDFs and 3D spheroid M
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The promotion effect of Semaphorin7a in peripheral nerve regeneration in vi...
Published: 11 April 2025
Figure 7.
The promotion effect of Semaphorin7a in peripheral nerve regeneration in vitro and in vivo. (A) Western blotting for Semaphorin7a in 3D spheroid MDFs with or without siRNA treatment. (B, C) The neurite lengths of DRG neurons tested by Tuj1 staining after coculturing with Semaphorin7a siRNA pretreate
Journal Article
Reprogramming of skin fibroblasts by 3D spheroid culture promotes peripheral nerve regeneration via the ID3/semaphorin7a pathway
Stem Cells Translational Medicine, Volume 14, Issue 3, March 2025, szaf005, https://doi.org/10.1093/stcltm/szaf005
Published: 11 April 2025
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Characterization of 3D spheroid MDFs through low attachment culture. (A), P...
Published: 11 April 2025
Figure 1.
Characterization of 3D spheroid MDFs through low attachment culture. (A), Phase-contrast images of monolayer MDFs and 3D spheroid MDFs. (B-G), RT-PCR testing for NPC-specific genes including Sox2, Nestin, Brn2, Blbp, Gpm6a and Pax6 in monolayer MDFs and 3D spheroid MDFs ( n = 3). (H, I), RT-PCR tes
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ID3 regulates the NPC properties of 3D spheroid MDFs. (A-C), RT-PCR testing...
Published: 11 April 2025
Figure 2.
ID3 regulates the NPC properties of 3D spheroid MDFs. (A-C), RT-PCR testing (A) ( n = 3), Western blotting (B) immunostaining (C) and the corresponding fluorescence intensity quantification (E) ( n = 8) for ID3 in monolayer MDFs and 3D spheroid MDFs. Immunostaining (D) and the corresponding fluore
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The neurite extending enhancement effects of 3D spheroid MDFs. (A, B) The n...
Published: 11 April 2025
Figure 3.
The neurite extending enhancement effects of 3D spheroid MDFs. (A, B) The neurite lengths of DRG neurons tested by Tuj1 staining after coculturing with monolayer MDFs or 3D spheroid MDFs ( n = 10). (C) Tuj1 immunostaining and the Dil labeled monolayer MDFs or 3D spheroid MDFs in the regenerated axo
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The whole gene expression profile comparing analysis of monolayer and 3D sp...
Published: 11 April 2025
Figure 5.
The whole gene expression profile comparing analysis of monolayer and 3D spheroid MDFs. (A) Whole-transcript expression profiling of monolayer and 3D spheroid MDFs. (B) The overlap gene numbers between monolayer and 3D spheroid MDFs. (C) Heatmap showing differential expressing genes in monolayer and
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Expressions of the immunoreactivity of muscarinic/purinergic receptors (A),...
Published: 01 April 2025
Figure 2.
Expressions of the immunoreactivity of muscarinic/purinergic receptors (A), inflammation and fibrosis markers (B), oxidative stress markers (C), apoptosis-associated mitochondrial proteins (D), and temporal profiles of immunohistochemistry and immunofluorescence expressions (E). Compared with normal
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Hematoxylin and eosin staining of the common iliac artery. Compared with no...
Published: 01 April 2025
Figure 4.
Hematoxylin and eosin staining of the common iliac artery. Compared with normal control group, OVX group has significantly increased wall thickness of the common iliac artery at 1 m. Ovariectomized rats with MetS (OVX + MetS) have significantly increased wall thickness at 1 and 3 m when compared wit
Journal Article
Bladder dysfunction in hypoestrogenic rats with metabolic syndrome can be ameliorated after amniotic fluid stem cell treatment
Stem Cells Translational Medicine, Volume 14, Issue 3, March 2025, szae100, https://doi.org/10.1093/stcltm/szae100
Published: 01 April 2025
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Relative mRNA expressions of muscarinic/purinergic receptors (A), inflammat...
Published: 01 April 2025
Figure 3.
Relative mRNA expressions of muscarinic/purinergic receptors (A), inflammation and fibrosis markers (B), and apoptosis-associated mitochondrial proteins (C). Compared with normal control group, ovariectomy (OVX) causes significantly increased mRNA expressions of M2/M3 and collagen 1 at 1 m and P2X3
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Histological features of bladder damage as represented by Masson’s trichrom...
Published: 01 April 2025
Figure 5.
Histological features of bladder damage as represented by Masson’s trichrome stain. The collagen is stained blue (arrowheads) and the muscle red (arrows). Compared with normal control, OVX and OVX + MetS groups have significantly increased bladder collagen volume at 1 and 3 m. After hAFSCs treatment
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Cystometric results of all groups are presented. In upper panel, cystometri...
Published: 01 April 2025
Figure 1.
Cystometric results of all groups are presented. In upper panel, cystometric variables include (A) peak voiding pressure, (B) peak voided volume, (C) intercontraction interval, (D) bladder capacity, (E) residual volume, and (F) nonvoiding contraction. Lower panel (G) depicts peak voiding pressure an
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Apoptosis study in the bladder using terminal deoxynucleotidyl transferase-...
Published: 01 April 2025
Figure 6.
Apoptosis study in the bladder using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. Compared with normal control, ovariectomy (OVX) induces nonsignificant increase of apoptotic cells (arrows). Ovariectomized rats with MetS (OVX + MetS) have markedly increased
Journal Article
Unveiling spontaneous renal tubule-like structures from human adult renal progenitor cell spheroids derived from urine
Stem Cells Translational Medicine, Volume 14, Issue 3, March 2025, szaf002, https://doi.org/10.1093/stcltm/szaf002
Published: 29 March 2025
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Expression of renal tubular markers in tubular-like structures. (A) Whole-m...
Published: 29 March 2025
Figure 4.
Expression of renal tubular markers in tubular-like structures. (A) Whole-mount immunofluorescence showing the expression of CD249 in tubular-like structures. (B) Whole-mount immunofluorescence showing that the tubule-like structures generated from spheroids were positive for CD13 (aminopontinidase
