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About the Journal

The mission of Toxicological Sciences is to publish the most influential research in the field of toxicology. The primary focus is on original and hypothesis-driven research articles. The journal also provides expert insight via contemporary reviews, as well as forum articles and editorials that address important topics in the field.

The scope of Toxicological Sciences is inclusive to attract significant contributions to toxicological research (from molecular mechanisms of toxic effects to safety evaluation and risk assessment), encompassing all technologies used in toxicology (from mass spectrometry and molecular biology to tissue culture, histopathology, and whole-animal studies). The editors encourage integrative approaches that combine exposure scenarios entailing multipathway exposures with multiple effects.

Examples of the focus of research articles published include:

  • Structural, functional, biochemical, and molecular effects of toxic agents
  • Studies that address mechanisms of toxicity
  • Relevant translational data for human health assessment
  • Statistical or mechanism-based approaches to risk assessment
  • Novel methods or approaches to studying toxicology

Types of Articles Published:


Policies and General Guidelines

Please review the journal’s Policies and General Guidelines, including: Conflicts of Interest, Peer Review, Public Access, Crossref Funding Data Registry, Research Involving Animals, Research Involving Human Subjects, and Manuscript Submission.

Manuscripts previously posted to a preprint server for comment are welcome.


Toxicological Sciences uses ScholarOne Manuscripts for online submission, located at http://mc.manuscriptcentral.com/toxsci. This system facilitates convenient uploading of original and revised manuscripts, as well as online reviewing and communication among authors, editors, and reviewers.

Research Articles. For complete preparation and submission instructions, see Information for Authors on the ToxSci home page.

Contemporary ReviewsToxicological Sciences publishes Contemporary Reviews (3,500 word limit), which provide expert analysis of important and emerging areas in the field of toxicology. All Contemporary Reviews require prior approval by the editor. A Contemporary Review Proposal "Manuscript Type" is available on the manuscript submission site for authors to propose a review on a particular topic. You will be asked to provide the basics of Title, Abstract, Keywords, Authors, etc., as well as: 

  • A compelling explanation of the need and timeliness of the Contemporary Review (<500 words). 
  • An estimated Submission Date. 
  • A list of 10-15 key references from within the last 3-5 years.

Contemporary Reviews will be made freely available to all readers; however, authors are responsible for printed color figure charges (figures are published in color online at no charge).

Forum. The Forum section includes discussions and commentaries providing an interface between toxicology and public policy. Commentaries should briefly discuss a sharply focused topic of recent relevant policy decisions or experimental research. These manuscripts must also provide a critical and balanced view of the issue or research area. It is expected that timely meetings and workshops will result in topics suitable for Forum articles. However, Toxicological Sciences does not publish meeting reports per se. Forum articles must be about the topic of interest in the field and not a particular meeting. Authors are encouraged to submit a Forum Proposal "Manuscript Type" via the manuscript submission site prior to manuscript submission. Forum articles are limited to 5,000 words. The use of supplementary data is encouraged to keep the printed version of the manuscript within the recommended limits.

Letters to the Editor. Letters to the Editor regarding published articles should be submitted within 2 months of mailing of the printed journal. Letters should have a descriptive title and must not exceed 1000 words, including references. References may be published as Supplementary Data at the journal’s discretion. Letters submitted outside these parameters will be returned with a revision request to conform to these requirements. Letters will be peer-reviewed for factual accuracy and originality. Unsubstantiated claims or opinions will not be permitted. Each accepted letter will be sent to the author(s) of the original paper so that any reply may be published simultaneously with the first letter. Final publication of either letter is at the discretion of the Editor.

Supplementary Data. Supplementary Data is supporting material that cannot be included in the printed version for reasons of space and that is not essential for inclusion in the full text of the manuscript but would nevertheless benefit the reader. It should not be essential to understanding the conclusions of the manuscript but should contain data that is additional or complementary and directly relevant to the manuscript content. For more detailed information, please see Supplementary Data Guidelines.

Dryad Digital Repository. Authors are encouraged to make original or raw data, images, and/or code available to the general scientific public as part of their publication by posting to the Dryad Digital Repository prior to manuscript acceptance.  The DOI number assigned to the data should be included in the Results section of the manuscript.

See Information for Authors for complete manuscript preparation and submission information.

Contact the Editorial Office (302-326-9313) with any specific questions.


Peer Review

Toxicological Sciences utilizes a single-blind peer review process in which the identities of the reviewers are concealed from the author(s) as well as each other.  For more information about peer review, see Policies and General Guidelines.

Advance Access

Accepted manuscripts are initially published ahead of print in their "Accepted Manuscript" form as soon as possible post-acceptance, generally within one week. More information, including how to cite Advance Access papers, can be found on the Advance Access page.

Impact Factor and Evaluating Journal Quality

Abstracting and Indexing

The journal is covered by the following services:
Abstracts in Anthropology
Abstracts on Hygiene and Communicable Diseases
Agbiotech News and Information
Animal Breeding Abstracts
Aquatic Sciences and Fisheries Abstracts
Biological Abstracts
BIOSIS Previews
CAB Abstracts
Chemical Abstracts
Chemical Safety Newsbase
Current Contents® /Life Sciences
Dairy Science Abstracts
Derwent Drug File
Directory of Open Access Journals (DOAJ)
Elsevier BIOBASE - Current Awareness in Biological Sciences (CABS)
Environment Index
Environmental Science and Pollution Management
Excerpta Medica Abstract Journals
Forest Products Abstracts
Forestry Abstracts
Global Health
Health & Safety Science Abstracts
Helminthology Abstracts
Horticultural Abstracts
Index Veterinarius
Journal Citation Reports /Science Edition
Laboratory Hazards Bulletin
Maize Abstracts Online
Nematological Abstracts
Nutrition Abstracts and Reviews
Nutrition Research Newsletter
Pharmacoeconomics and Outcome News
Pig News & Information
Plant Breeding Abstracts
Pollution Abstracts
Post Harvest News and Information
Reactions Weekly
Review of Agricultural Entomology
Review of Aromatic and Medicinal Plants
Review of Medical and Veterinary Mycology
Review of Plant Pathology
Science Citation Index Expanded (SciSearch®)
Science Citation Index
Soybean Abstracts
Sugar Industry Abstracts
The Standard Periodical Directory
Toxicology Abstracts
Tropical Diseases Bulletin
Veterinary Bulletin
Water Resources Abstracts
Weed Abstracts
Wildlife Review
World Agricultural Economics and Rural Sociology Abstracts

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