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Contemporary Reviews

Toxicological Sciences publishes Contemporary Reviews which provide expert analysis of important and emerging areas in the field of toxicology. These articles are freely available to all readers.

Viral Vectors: The Road to Reducing Genotoxicity
Rhiannon M. David and Ann T. Doherty

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology
Clemens Wittwehr, Hristo Aladjov, Gerald Ankley, Hugh J. Byrne, Joop de Knecht, et. al

Long Non-Coding RNAs: A Novel Paradigm for Toxicology
Joseph L. Dempsey and Julia Yue Cui

Linking the Epigenome with Exposure Effects and Susceptibility: The Epigenetic Seed and Soil Model
Emma C. Bowers and Shaun D. McCullough

Mechanisms of Action Point Towards Combined PBDE/NDL-PCB Risk Assessment
Milou M.L. Dingemans, Marjolijn Kock and Martin van den Berg

MicroRNA Biomarkers of Toxicity in Biological Matrices
Alison H. Harrill, Shaun D. McCullough, Charles E. Wood, Juliette J. Kahle and Brian N. Chorley

Safety Evaluation of CNS Administered Biologics—Study Design, Data Interpretation, and Translation to the Clinic

Brian R. Vuillemenot, Sven Korte, Teresa L. Wright, Eric L. Adams, et. al

Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis
Michelle M. Angrish, Jonathan Phillip Kaiser, Charlene A. McQueen and Brian N. Chorley

Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis
Gloria Ravegnini, Gulia Sammarini, Patrizia Hrelia and Sabrina Angelini 

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment 
Qiang Zhang, Sudin Bhattacharya, Jingbo Pi, et. al 

At the Crossroads of Nanotoxicology in vitro: Past Achievements and Current Challenges
Saber M. Hussain, David B. Warheit, Sheung P. Ng, Kristen K. Comfort, et. al 

Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson’s Disease: Environmental and Genetic Evidence Tomás R. Guilarte and Kalynda K. Gonzales 

Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective
Sree Rayavarapu, Elena Braithwaite, Robert Dorsam, James Osterhout, et. al 

Polycyclic Aromatic Hydrocarbons: From Metabolism to Lung Cancer
Bhagavatula Moorthy, Chun Chu and Danielle J. Carlin 

Biomarkers for the 21st Century: Listening to the Microbiome
Rodney Reynolds Dietert and Ellen Kovner Silbergeld 

The Role of Astrocyte Mitochondria in Differential Regional Susceptibility to Environmental Neurotoxicants: Tools for Understanding Neurodegeneration
Laura L. Kubik and Martin A. Philbert 

Air Pollution as a Risk Factor for Type 2 Diabetes
Xiaoquan Rao, Priti Patel, Robin Puett and Sanjay Rajagopalan

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