The clinico-laboratory profile of six patients with vivax cerebral malaria was studied. Presenting features were of an acute febrile encephalopathy, convulsions and coma. Focal neurological signs were observed in one patient. Associated renal failure, circulating immune complexes and low serum C3 complement levels were detected in 2 cases. Serum albumin levels were low in 4 cases. Four children expired, the survivors had no residual sequalae. Hypoalbuminemia, renal failure and deep coma were poor prognostic indicators. The possible pathogenetic mechanisms are discussed.