Summary of cell types analyzed in this study. For LCL and iPSC samples, ‘unique individuals’ excludes repeated clones or sequencing of the same individual. In HAP1, all cell lines were derived from a single individual therefore ‘unique mutant samples’ signifies different KO types. HAP1 also includes 26 KO lines involving 22 genes with three genes having multiple KO clones. Among the 26 KO lines, some were sequenced before and after diploidization and are considered the same unique mutant sample. See Supplementary Material, Table S1 for more details