Table 3 Open in new tab Risk of stroke...

Smoking status	No.	Stroke
All current smokers	Quitter	Quitter (sustained)	91 189	1034	2.6	1 (Ref.)	1 (Ref.)	1.22 (1.14–1.29)	—
Reducer I (relapser)	8535	145	3.9	1.51 (1.27–1.80)	1.42 (1.20–1.69)	1.72 (1.44–2.00)	0.50 (0.22–0.79)
Reducer II (relapser)	8819	138	3.6	1.38 (1.16–1.65)	1.66 (1.39–1.98)	2.00 (1.67–2.32)	0.78 (0.44–1.11)
Sustainer + Increaser	34 884	508	3.4	1.29 (1.16–1.44)	1.51 (1.35–1.68)	1.82 (1.66–1.98)	0.61 (0.43–0.78)
Reducer I	Quitter	10 220	175	4.0	0.89 (0.74–1.07)	0.84 (0.70–1.01)	1.73 (1.47–1.99)	−0.32 (−0.65 to 0.02)
Reducer I	17 331	331	4.5	1 (Ref.)	1 (Ref.)	2.05 (1.82–2.27)	—
Reducer II	7238	119	3.8	0.85 (0.69–1.05)	1.01 (0.82–1.25)	2.07 (1.70–2.44)	0.02 (−0.40 to 0.45)
Sustainer + Increaser	14 079	232	3.8	0.86 (0.73–1.01)	0.97 (0.82–1.15)	1.99 (1.73–2.24)	−0.06 (−0.39 to 0.27)
Reducer II	Quitter	12 332	138	2.6	0.90 (0.74–1.09)	0.70 (0.57–0.85)	1.10 (0.91–1.29)	−0.47 (−0.71 to −0.23)
Reducer I	10 327	189	4.3	1.48 (1.24–1.76)	1.20 (1.01–1.43)	1.88 (1.60–2.15)	0.30 (0.00–0.61)
Reducer II	31 724	394	2.9	1 (Ref.)	1 (Ref.)	1.58 (1.41–1.74)	—
Sustainer + Increaser	25 063	343	3.2	1.10 (0.95–1.27)	1.06 (0.91–1.22)	1.66 (1.47–1.85)	0.09 (−0.14 to 0.32)
Sustainer + Increaser	Quitter	61 618	798	3.0	0.97 (0.90–1.05)	0.80 (0.74–0.86)	1.26 (1.17–1.34)	−0.31 (−0.41 to −0.21)
Reducer I	22 756	404	4.1	1.35 (1.21–1.49)	1.02 (0.92–1.13)	1.60 (1.44–1.75)	0.03 (−0.13 to 0.19)
Reducer II	39 403	507	3.0	0.97 (0.88–1.06)	0.96 (0.87–1.05)	1.50 (1.37–1.63)	−0.07 (−0.21 to 0.07)
Sustainer + Increaser	290 809	3864	3.1	1 (Ref.)	1 (Ref.)	1.56 (1.51–1.62)	—

Smoking status

No.

Stroke

2009

2011

2013^a

Case no.

IR per 1000 person-years

HR (95% CI)

aHR^b (95% CI)

5-Year absolute risk (%) (95% CI)

Risk difference (95% CI)

All current smokers

Quitter

Quitter (sustained)

91 189

1034

2.6

1 (Ref.)

1.22 (1.14–1.29)

—

Reducer I (relapser)

8535

145

3.9

1.51 (1.27–1.80)

1.42 (1.20–1.69)

1.72 (1.44–2.00)

0.50 (0.22–0.79)

Reducer II (relapser)

8819

138

3.6

1.38 (1.16–1.65)

1.66 (1.39–1.98)

2.00 (1.67–2.32)

0.78 (0.44–1.11)

Sustainer + Increaser

34 884

508

3.4

1.29 (1.16–1.44)

1.51 (1.35–1.68)

1.82 (1.66–1.98)

0.61 (0.43–0.78)

Reducer I

Quitter

10 220

175

4.0

0.89 (0.74–1.07)

0.84 (0.70–1.01)

1.73 (1.47–1.99)

−0.32 (−0.65 to 0.02)

Reducer I

17 331

331

4.5

1 (Ref.)

2.05 (1.82–2.27)

—

Reducer II

7238

119

3.8

0.85 (0.69–1.05)

1.01 (0.82–1.25)

2.07 (1.70–2.44)

0.02 (−0.40 to 0.45)

Sustainer + Increaser

14 079

232

3.8

0.86 (0.73–1.01)

0.97 (0.82–1.15)

1.99 (1.73–2.24)

−0.06 (−0.39 to 0.27)

Reducer II

Quitter

12 332

138

2.6

0.90 (0.74–1.09)

0.70 (0.57–0.85)

1.10 (0.91–1.29)

−0.47 (−0.71 to −0.23)

Reducer I

10 327

189

4.3

1.48 (1.24–1.76)

1.20 (1.01–1.43)

1.88 (1.60–2.15)

0.30 (0.00–0.61)

Reducer II

31 724

394

2.9

1 (Ref.)

1.58 (1.41–1.74)

—

Sustainer + Increaser

25 063

343

3.2

1.10 (0.95–1.27)

1.06 (0.91–1.22)

1.66 (1.47–1.85)

0.09 (−0.14 to 0.32)

Sustainer + Increaser

Quitter

61 618

798

3.0

0.97 (0.90–1.05)

0.80 (0.74–0.86)

1.26 (1.17–1.34)

−0.31 (−0.41 to −0.21)

Reducer I

22 756

404

4.1

1.35 (1.21–1.49)

1.02 (0.92–1.13)

1.60 (1.44–1.75)

0.03 (−0.13 to 0.19)

Reducer II

39 403

507

3.0

0.97 (0.88–1.06)

0.96 (0.87–1.05)

1.50 (1.37–1.63)

−0.07 (−0.21 to 0.07)

Sustainer + Increaser

290 809

3864

3.1

1 (Ref.)

1.56 (1.51–1.62)

—

Smoking status	No.	Stroke
All current smokers	Quitter	Quitter (sustained)	91 189	1034	2.6	1 (Ref.)	1 (Ref.)	1.22 (1.14–1.29)	—
Reducer I (relapser)	8535	145	3.9	1.51 (1.27–1.80)	1.42 (1.20–1.69)	1.72 (1.44–2.00)	0.50 (0.22–0.79)
Reducer II (relapser)	8819	138	3.6	1.38 (1.16–1.65)	1.66 (1.39–1.98)	2.00 (1.67–2.32)	0.78 (0.44–1.11)
Sustainer + Increaser	34 884	508	3.4	1.29 (1.16–1.44)	1.51 (1.35–1.68)	1.82 (1.66–1.98)	0.61 (0.43–0.78)
Reducer I	Quitter	10 220	175	4.0	0.89 (0.74–1.07)	0.84 (0.70–1.01)	1.73 (1.47–1.99)	−0.32 (−0.65 to 0.02)
Reducer I	17 331	331	4.5	1 (Ref.)	1 (Ref.)	2.05 (1.82–2.27)	—
Reducer II	7238	119	3.8	0.85 (0.69–1.05)	1.01 (0.82–1.25)	2.07 (1.70–2.44)	0.02 (−0.40 to 0.45)
Sustainer + Increaser	14 079	232	3.8	0.86 (0.73–1.01)	0.97 (0.82–1.15)	1.99 (1.73–2.24)	−0.06 (−0.39 to 0.27)
Reducer II	Quitter	12 332	138	2.6	0.90 (0.74–1.09)	0.70 (0.57–0.85)	1.10 (0.91–1.29)	−0.47 (−0.71 to −0.23)
Reducer I	10 327	189	4.3	1.48 (1.24–1.76)	1.20 (1.01–1.43)	1.88 (1.60–2.15)	0.30 (0.00–0.61)
Reducer II	31 724	394	2.9	1 (Ref.)	1 (Ref.)	1.58 (1.41–1.74)	—
Sustainer + Increaser	25 063	343	3.2	1.10 (0.95–1.27)	1.06 (0.91–1.22)	1.66 (1.47–1.85)	0.09 (−0.14 to 0.32)
Sustainer + Increaser	Quitter	61 618	798	3.0	0.97 (0.90–1.05)	0.80 (0.74–0.86)	1.26 (1.17–1.34)	−0.31 (−0.41 to −0.21)
Reducer I	22 756	404	4.1	1.35 (1.21–1.49)	1.02 (0.92–1.13)	1.60 (1.44–1.75)	0.03 (−0.13 to 0.19)
Reducer II	39 403	507	3.0	0.97 (0.88–1.06)	0.96 (0.87–1.05)	1.50 (1.37–1.63)	−0.07 (−0.21 to 0.07)
Sustainer + Increaser	290 809	3864	3.1	1 (Ref.)	1 (Ref.)	1.56 (1.51–1.62)	—

Smoking status	No.	Myocardial infarction
All current smokers	Quitter	Quitter (sustained)	91 189	602	1.5	1 (Ref.)	1 (Ref.)	0.74 (0.67–0.80)	—
Reducer I (relapser)	8535	100	2.7	1.79 (1.45–2.21)	1.69 (1.36–2.09)	1.23 (0.99–1.48)	0.50 (0.25–0.75)
Reducer II (relapser)	8819	83	2.2	1.43 (1.13–1.80)	1.54 (1.23–1.94)	1.13 (0.89–1.38)	0.40 (0.15–0.65)
Sustainer + Increaser	34 884	355	2.3	1.55 (1.36–1.77)	1.67 (1.46–1.91)	1.22 (1.09–1.35)	0.49 (0.34–0.63)
Reducer I	Quitter	10 220	101	2.3	0.91 (0.71–1.15)	0.89 (0.70–1.14)	1.12 (0.88–1.36)	−0.14 (−0.42 to 0.15)
Reducer I	17 331	188	2.5	1 (Ref.)	1 (Ref.)	1.25 (1.05–1.46)	—
Reducer II	7238	74	2.4	0.94 (0.72–1.23)	1.04 (0.80–1.37)	1.31 (0.99–1.62)	0.05 (−0.29 to 0.40)
Sustainer + Increaser	14 079	145	2.4	0.95 (0.76–1.17)	1.01 (0.81–1.26)	1.27 (1.04–1.50)	0.01 (−0.26 to 0.28)
Reducer II	Quitter	12 332	98	1.8	0.92 (0.73–1.16)	0.82 (0.65–1.04)	0.81 (0.65–0.97)	−0.17 (−0.37 to 0.03)
Reducer I	10 327	91	2.0	1.03 (0.81–1.31)	0.93 (0.74–1.18)	0.92 (0.73–1.11)	−0.07 (−0.29 to 0.15)
Reducer II	31 724	272	2.0	1 (Ref.)	1 (Ref.)	0.98 (0.86–1.10)	—
Sustainer + Increaser	25 063	250	2.3	1.16 (0.98–1.38)	1.16 (0.98–1.38)	1.14 (0.99–1.28)	0.15 (−0.03 to 0.33)
Sustainer + Increaser	Quitter	61 618	506	1.9	0.90 (0.81–0.99)	0.80 (0.72–0.88)	0.89 (0.81–0.98)	−0.23 (−0.32 to −0.14)
Reducer I	22 756	228	2.3	1.10 (0.96–1.26)	0.93 (0.81–1.07)	1.05 (0.90–1.19)	−0.08 (−0.22 to 0.07)
Reducer II	39 403	315	1.8	0.88 (0.78–0.98)	0.87 (0.77–0.97)	0.97 (0.86–1.09)	−0.15 (−0.26 to −0.03)
Sustainer + Increaser	290 809	2659	2.1	1 (Ref.)	1 (Ref.)	1.12 (1.06–1.19)	—

Smoking status

No.

Myocardial infarction

2009

2011

2013^a

Case no.

IR per 1000 person-years

HR (95% CI)

aHR^b (95% CI)

5-Year absolute risk (%) (95% CI)

Risk difference (95% CI)

All current smokers

Quitter

Quitter (sustained)

91 189

602

1.5

1 (Ref.)

0.74 (0.67–0.80)

—

Reducer I (relapser)

8535

100

2.7

1.79 (1.45–2.21)

1.69 (1.36–2.09)

1.23 (0.99–1.48)

0.50 (0.25–0.75)

Reducer II (relapser)

8819

2.2

1.43 (1.13–1.80)

1.54 (1.23–1.94)

1.13 (0.89–1.38)

0.40 (0.15–0.65)

Sustainer + Increaser

34 884

355

2.3

1.55 (1.36–1.77)

1.67 (1.46–1.91)

1.22 (1.09–1.35)

0.49 (0.34–0.63)

Reducer I

Quitter

10 220

101

2.3

0.91 (0.71–1.15)

0.89 (0.70–1.14)

1.12 (0.88–1.36)

−0.14 (−0.42 to 0.15)

Reducer I

17 331

188

2.5

1 (Ref.)

1.25 (1.05–1.46)

—

Reducer II

7238

2.4

0.94 (0.72–1.23)

1.04 (0.80–1.37)

1.31 (0.99–1.62)

0.05 (−0.29 to 0.40)

Sustainer + Increaser

14 079

145

2.4

0.95 (0.76–1.17)

1.01 (0.81–1.26)

1.27 (1.04–1.50)

0.01 (−0.26 to 0.28)

Reducer II

Quitter

12 332

1.8

0.92 (0.73–1.16)

0.82 (0.65–1.04)

0.81 (0.65–0.97)

−0.17 (−0.37 to 0.03)

Reducer I

10 327

2.0

1.03 (0.81–1.31)

0.93 (0.74–1.18)

0.92 (0.73–1.11)

−0.07 (−0.29 to 0.15)

Reducer II

31 724

272

2.0

1 (Ref.)

0.98 (0.86–1.10)

—

Sustainer + Increaser

25 063

250

2.3

1.16 (0.98–1.38)

1.14 (0.99–1.28)

0.15 (−0.03 to 0.33)

Sustainer + Increaser

Quitter

61 618

506

1.9

0.90 (0.81–0.99)

0.80 (0.72–0.88)

0.89 (0.81–0.98)

−0.23 (−0.32 to −0.14)

Reducer I

22 756

228

2.3

1.10 (0.96–1.26)

0.93 (0.81–1.07)

1.05 (0.90–1.19)

−0.08 (−0.22 to 0.07)

Reducer II

39 403

315

1.8

0.88 (0.78–0.98)

0.87 (0.77–0.97)

0.97 (0.86–1.09)

−0.15 (−0.26 to −0.03)

Sustainer + Increaser

290 809

2659

2.1

1 (Ref.)

1.12 (1.06–1.19)

—

Smoking status	No.	Myocardial infarction
All current smokers	Quitter	Quitter (sustained)	91 189	602	1.5	1 (Ref.)	1 (Ref.)	0.74 (0.67–0.80)	—
Reducer I (relapser)	8535	100	2.7	1.79 (1.45–2.21)	1.69 (1.36–2.09)	1.23 (0.99–1.48)	0.50 (0.25–0.75)
Reducer II (relapser)	8819	83	2.2	1.43 (1.13–1.80)	1.54 (1.23–1.94)	1.13 (0.89–1.38)	0.40 (0.15–0.65)
Sustainer + Increaser	34 884	355	2.3	1.55 (1.36–1.77)	1.67 (1.46–1.91)	1.22 (1.09–1.35)	0.49 (0.34–0.63)
Reducer I	Quitter	10 220	101	2.3	0.91 (0.71–1.15)	0.89 (0.70–1.14)	1.12 (0.88–1.36)	−0.14 (−0.42 to 0.15)
Reducer I	17 331	188	2.5	1 (Ref.)	1 (Ref.)	1.25 (1.05–1.46)	—
Reducer II	7238	74	2.4	0.94 (0.72–1.23)	1.04 (0.80–1.37)	1.31 (0.99–1.62)	0.05 (−0.29 to 0.40)
Sustainer + Increaser	14 079	145	2.4	0.95 (0.76–1.17)	1.01 (0.81–1.26)	1.27 (1.04–1.50)	0.01 (−0.26 to 0.28)
Reducer II	Quitter	12 332	98	1.8	0.92 (0.73–1.16)	0.82 (0.65–1.04)	0.81 (0.65–0.97)	−0.17 (−0.37 to 0.03)
Reducer I	10 327	91	2.0	1.03 (0.81–1.31)	0.93 (0.74–1.18)	0.92 (0.73–1.11)	−0.07 (−0.29 to 0.15)
Reducer II	31 724	272	2.0	1 (Ref.)	1 (Ref.)	0.98 (0.86–1.10)	—
Sustainer + Increaser	25 063	250	2.3	1.16 (0.98–1.38)	1.16 (0.98–1.38)	1.14 (0.99–1.28)	0.15 (−0.03 to 0.33)
Sustainer + Increaser	Quitter	61 618	506	1.9	0.90 (0.81–0.99)	0.80 (0.72–0.88)	0.89 (0.81–0.98)	−0.23 (−0.32 to −0.14)
Reducer I	22 756	228	2.3	1.10 (0.96–1.26)	0.93 (0.81–1.07)	1.05 (0.90–1.19)	−0.08 (−0.22 to 0.07)
Reducer II	39 403	315	1.8	0.88 (0.78–0.98)	0.87 (0.77–0.97)	0.97 (0.86–1.09)	−0.15 (−0.26 to −0.03)
Sustainer + Increaser	290 809	2659	2.1	1 (Ref.)	1 (Ref.)	1.12 (1.06–1.19)	—

Table 3

Open in new tab

Risk of stroke or myocardial infarction by change in cigarette smoking intensity at the third examination (2013)

Smoking status			No.	Stroke
2009	2011	2013^a	No.	Case no.	IR per 1000 person-years	HR (95% CI)	aHR^b (95% CI)	5-Year absolute risk (%) (95% CI)	Risk difference (95% CI)
All current smokers	Quitter	Quitter (sustained)	91 189	1034	2.6	1 (Ref.)	1 (Ref.)	1.22 (1.14–1.29)	—
		Reducer I (relapser)	8535	145	3.9	1.51 (1.27–1.80)	1.42 (1.20–1.69)	1.72 (1.44–2.00)	0.50 (0.22–0.79)
		Reducer II (relapser)	8819	138	3.6	1.38 (1.16–1.65)	1.66 (1.39–1.98)	2.00 (1.67–2.32)	0.78 (0.44–1.11)
		Sustainer + Increaser	34 884	508	3.4	1.29 (1.16–1.44)	1.51 (1.35–1.68)	1.82 (1.66–1.98)	0.61 (0.43–0.78)
	Reducer I	Quitter	10 220	175	4.0	0.89 (0.74–1.07)	0.84 (0.70–1.01)	1.73 (1.47–1.99)	−0.32 (−0.65 to 0.02)
		Reducer I	17 331	331	4.5	1 (Ref.)	1 (Ref.)	2.05 (1.82–2.27)	—
		Reducer II	7238	119	3.8	0.85 (0.69–1.05)	1.01 (0.82–1.25)	2.07 (1.70–2.44)	0.02 (−0.40 to 0.45)
		Sustainer + Increaser	14 079	232	3.8	0.86 (0.73–1.01)	0.97 (0.82–1.15)	1.99 (1.73–2.24)	−0.06 (−0.39 to 0.27)
	Reducer II	Quitter	12 332	138	2.6	0.90 (0.74–1.09)	0.70 (0.57–0.85)	1.10 (0.91–1.29)	−0.47 (−0.71 to −0.23)
		Reducer I	10 327	189	4.3	1.48 (1.24–1.76)	1.20 (1.01–1.43)	1.88 (1.60–2.15)	0.30 (0.00–0.61)
		Reducer II	31 724	394	2.9	1 (Ref.)	1 (Ref.)	1.58 (1.41–1.74)	—
		Sustainer + Increaser	25 063	343	3.2	1.10 (0.95–1.27)	1.06 (0.91–1.22)	1.66 (1.47–1.85)	0.09 (−0.14 to 0.32)
	Sustainer + Increaser	Quitter	61 618	798	3.0	0.97 (0.90–1.05)	0.80 (0.74–0.86)	1.26 (1.17–1.34)	−0.31 (−0.41 to −0.21)
		Reducer I	22 756	404	4.1	1.35 (1.21–1.49)	1.02 (0.92–1.13)	1.60 (1.44–1.75)	0.03 (−0.13 to 0.19)
		Reducer II	39 403	507	3.0	0.97 (0.88–1.06)	0.96 (0.87–1.05)	1.50 (1.37–1.63)	−0.07 (−0.21 to 0.07)
		Sustainer + Increaser	290 809	3864	3.1	1 (Ref.)	1 (Ref.)	1.56 (1.51–1.62)	—

Smoking status			No.	Stroke
2009	2011	2013^a	No.	Case no.	IR per 1000 person-years	HR (95% CI)	aHR^b (95% CI)	5-Year absolute risk (%) (95% CI)	Risk difference (95% CI)
All current smokers	Quitter	Quitter (sustained)	91 189	1034	2.6	1 (Ref.)	1 (Ref.)	1.22 (1.14–1.29)	—
		Reducer I (relapser)	8535	145	3.9	1.51 (1.27–1.80)	1.42 (1.20–1.69)	1.72 (1.44–2.00)	0.50 (0.22–0.79)
		Reducer II (relapser)	8819	138	3.6	1.38 (1.16–1.65)	1.66 (1.39–1.98)	2.00 (1.67–2.32)	0.78 (0.44–1.11)
		Sustainer + Increaser	34 884	508	3.4	1.29 (1.16–1.44)	1.51 (1.35–1.68)	1.82 (1.66–1.98)	0.61 (0.43–0.78)
	Reducer I	Quitter	10 220	175	4.0	0.89 (0.74–1.07)	0.84 (0.70–1.01)	1.73 (1.47–1.99)	−0.32 (−0.65 to 0.02)
		Reducer I	17 331	331	4.5	1 (Ref.)	1 (Ref.)	2.05 (1.82–2.27)	—
		Reducer II	7238	119	3.8	0.85 (0.69–1.05)	1.01 (0.82–1.25)	2.07 (1.70–2.44)	0.02 (−0.40 to 0.45)
		Sustainer + Increaser	14 079	232	3.8	0.86 (0.73–1.01)	0.97 (0.82–1.15)	1.99 (1.73–2.24)	−0.06 (−0.39 to 0.27)
	Reducer II	Quitter	12 332	138	2.6	0.90 (0.74–1.09)	0.70 (0.57–0.85)	1.10 (0.91–1.29)	−0.47 (−0.71 to −0.23)
		Reducer I	10 327	189	4.3	1.48 (1.24–1.76)	1.20 (1.01–1.43)	1.88 (1.60–2.15)	0.30 (0.00–0.61)
		Reducer II	31 724	394	2.9	1 (Ref.)	1 (Ref.)	1.58 (1.41–1.74)	—
		Sustainer + Increaser	25 063	343	3.2	1.10 (0.95–1.27)	1.06 (0.91–1.22)	1.66 (1.47–1.85)	0.09 (−0.14 to 0.32)
	Sustainer + Increaser	Quitter	61 618	798	3.0	0.97 (0.90–1.05)	0.80 (0.74–0.86)	1.26 (1.17–1.34)	−0.31 (−0.41 to −0.21)
		Reducer I	22 756	404	4.1	1.35 (1.21–1.49)	1.02 (0.92–1.13)	1.60 (1.44–1.75)	0.03 (−0.13 to 0.19)
		Reducer II	39 403	507	3.0	0.97 (0.88–1.06)	0.96 (0.87–1.05)	1.50 (1.37–1.63)	−0.07 (−0.21 to 0.07)
		Sustainer + Increaser	290 809	3864	3.1	1 (Ref.)	1 (Ref.)	1.56 (1.51–1.62)	—

Smoking status			No.	Myocardial infarction
2009	2011	2013^a	No.	Case no.	IR per 1000 person-years	HR (95% CI)	aHR^b (95% CI)	5-Year absolute risk (%) (95% CI)	Risk difference (95% CI)
All current smokers	Quitter	Quitter (sustained)	91 189	602	1.5	1 (Ref.)	1 (Ref.)	0.74 (0.67–0.80)	—
		Reducer I (relapser)	8535	100	2.7	1.79 (1.45–2.21)	1.69 (1.36–2.09)	1.23 (0.99–1.48)	0.50 (0.25–0.75)
		Reducer II (relapser)	8819	83	2.2	1.43 (1.13–1.80)	1.54 (1.23–1.94)	1.13 (0.89–1.38)	0.40 (0.15–0.65)
		Sustainer + Increaser	34 884	355	2.3	1.55 (1.36–1.77)	1.67 (1.46–1.91)	1.22 (1.09–1.35)	0.49 (0.34–0.63)
	Reducer I	Quitter	10 220	101	2.3	0.91 (0.71–1.15)	0.89 (0.70–1.14)	1.12 (0.88–1.36)	−0.14 (−0.42 to 0.15)
		Reducer I	17 331	188	2.5	1 (Ref.)	1 (Ref.)	1.25 (1.05–1.46)	—
		Reducer II	7238	74	2.4	0.94 (0.72–1.23)	1.04 (0.80–1.37)	1.31 (0.99–1.62)	0.05 (−0.29 to 0.40)
		Sustainer + Increaser	14 079	145	2.4	0.95 (0.76–1.17)	1.01 (0.81–1.26)	1.27 (1.04–1.50)	0.01 (−0.26 to 0.28)
	Reducer II	Quitter	12 332	98	1.8	0.92 (0.73–1.16)	0.82 (0.65–1.04)	0.81 (0.65–0.97)	−0.17 (−0.37 to 0.03)
		Reducer I	10 327	91	2.0	1.03 (0.81–1.31)	0.93 (0.74–1.18)	0.92 (0.73–1.11)	−0.07 (−0.29 to 0.15)
		Reducer II	31 724	272	2.0	1 (Ref.)	1 (Ref.)	0.98 (0.86–1.10)	—
		Sustainer + Increaser	25 063	250	2.3	1.16 (0.98–1.38)	1.16 (0.98–1.38)	1.14 (0.99–1.28)	0.15 (−0.03 to 0.33)
	Sustainer + Increaser	Quitter	61 618	506	1.9	0.90 (0.81–0.99)	0.80 (0.72–0.88)	0.89 (0.81–0.98)	−0.23 (−0.32 to −0.14)
		Reducer I	22 756	228	2.3	1.10 (0.96–1.26)	0.93 (0.81–1.07)	1.05 (0.90–1.19)	−0.08 (−0.22 to 0.07)
		Reducer II	39 403	315	1.8	0.88 (0.78–0.98)	0.87 (0.77–0.97)	0.97 (0.86–1.09)	−0.15 (−0.26 to −0.03)
		Sustainer + Increaser	290 809	2659	2.1	1 (Ref.)	1 (Ref.)	1.12 (1.06–1.19)	—

Smoking status			No.	Myocardial infarction
2009	2011	2013^a	No.	Case no.	IR per 1000 person-years	HR (95% CI)	aHR^b (95% CI)	5-Year absolute risk (%) (95% CI)	Risk difference (95% CI)
All current smokers	Quitter	Quitter (sustained)	91 189	602	1.5	1 (Ref.)	1 (Ref.)	0.74 (0.67–0.80)	—
		Reducer I (relapser)	8535	100	2.7	1.79 (1.45–2.21)	1.69 (1.36–2.09)	1.23 (0.99–1.48)	0.50 (0.25–0.75)
		Reducer II (relapser)	8819	83	2.2	1.43 (1.13–1.80)	1.54 (1.23–1.94)	1.13 (0.89–1.38)	0.40 (0.15–0.65)
		Sustainer + Increaser	34 884	355	2.3	1.55 (1.36–1.77)	1.67 (1.46–1.91)	1.22 (1.09–1.35)	0.49 (0.34–0.63)
	Reducer I	Quitter	10 220	101	2.3	0.91 (0.71–1.15)	0.89 (0.70–1.14)	1.12 (0.88–1.36)	−0.14 (−0.42 to 0.15)
		Reducer I	17 331	188	2.5	1 (Ref.)	1 (Ref.)	1.25 (1.05–1.46)	—
		Reducer II	7238	74	2.4	0.94 (0.72–1.23)	1.04 (0.80–1.37)	1.31 (0.99–1.62)	0.05 (−0.29 to 0.40)
		Sustainer + Increaser	14 079	145	2.4	0.95 (0.76–1.17)	1.01 (0.81–1.26)	1.27 (1.04–1.50)	0.01 (−0.26 to 0.28)
	Reducer II	Quitter	12 332	98	1.8	0.92 (0.73–1.16)	0.82 (0.65–1.04)	0.81 (0.65–0.97)	−0.17 (−0.37 to 0.03)
		Reducer I	10 327	91	2.0	1.03 (0.81–1.31)	0.93 (0.74–1.18)	0.92 (0.73–1.11)	−0.07 (−0.29 to 0.15)
		Reducer II	31 724	272	2.0	1 (Ref.)	1 (Ref.)	0.98 (0.86–1.10)	—
		Sustainer + Increaser	25 063	250	2.3	1.16 (0.98–1.38)	1.16 (0.98–1.38)	1.14 (0.99–1.28)	0.15 (−0.03 to 0.33)
	Sustainer + Increaser	Quitter	61 618	506	1.9	0.90 (0.81–0.99)	0.80 (0.72–0.88)	0.89 (0.81–0.98)	−0.23 (−0.32 to −0.14)
		Reducer I	22 756	228	2.3	1.10 (0.96–1.26)	0.93 (0.81–1.07)	1.05 (0.90–1.19)	−0.08 (−0.22 to 0.07)
		Reducer II	39 403	315	1.8	0.88 (0.78–0.98)	0.87 (0.77–0.97)	0.97 (0.86–1.09)	−0.15 (−0.26 to −0.03)
		Sustainer + Increaser	290 809	2659	2.1	1 (Ref.)	1 (Ref.)	1.12 (1.06–1.19)	—

aHR, adjusted hazard ratio; CI, confidence interval; HR, hazard ratio; IR, incidence rate.

Compared to smoking amount at first examination in 2009.

Adjusted for age, sex, body mass index, smoking duration, alcohol consumption, regular exercise, area of residence, income, hypertension, diabetes mellitus, dyslipidaemia, and chronic kidney disease. Statistically significant values are marked in bold.

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