Table 1 Open in new tab Tissue content...

	DA	DOPAC	HVA	DOPAC/DA
OF	10.8 ± 1.2	11.2 ± 0.96	26 ± 3	25 ± 3	69 ± 10	45 ± 3^*	2.48 ± 0.2	2.36 ± 0.31
PL	41 ± 5	29 ± 4	17 ± 2	16 ± 3	116 ± 8	86 ± 11^*	0.54 ± 0.08	0.55 ± 0.05
aCg	89 ± 12	80 ± 7	75 ± 9	67 ± 7	213 ± 23	201 ± 24	0.79 ± 0.09	0.84 ± 0.08
NAC	1591 ± 266	1544 ± 215	904 ± 136	1036 ± 109	601 ± 112	620 ± 59	0.6 ± 0.05	0.76 ± 0.11
DMS	4107 ± 356	4535 ± 1047	1561 ± 162	1496 ± 195	670 ± 74	723 ± 143	0.36 ± 0.03	0.39 ± 0.04
DLS	6064 ± 666	5028 ± 176	802 ± 92	790 ± 82	500 ± 60	448 ± 20	0.13 ± 0.01	0.15 ± 0.01
Th	6 ± 0.9	8 ± 1	20 ± 1	22 ± 2	72 ± 8	77 ± 6	3.85 ± 0.58	2.67 ± 0.22
AM	240 ± 54	287 ± 48.8	83 ± 19	121 ± 26	150 ± 22.6	215 ± 49	0.33 ± 0.05	0.46 ± 0.09
dH	48 ± 6	44 ± 4	13 ± 1.8	13 ± 2	39 ± 3.78	41.8 ± 5.3	0.3 ± 0.03	0.3 ± 0.02
VTA	215 ± 41	234 ± 38	191 ± 37	207 ± 27	205 ± 30.1	239 ± 18.8	0.88 ± 0.05	0.91 ± 0.06
SN	259 ± 54	223 ± 46	141 ± 15	136 ± 21	265 ± 36	252 ± 40.3	0.64 ± 0.04	0.76 ± 0.04^*
vY	128 ± 19	106 ± 14	105 ± 8	101 ± 13.1	171 ± 18.8	136 ± 16.9	0.98 ± 0.07	0.99 ± 0.08

DOPAC

HVA

DOPAC/DA

region

SNORD

10.8 ± 1.2

11.2 ± 0.96

26 ± 3

25 ± 3

69 ± 10

45 ± 3^*

2.48 ± 0.2

2.36 ± 0.31

41 ± 5

29 ± 4

17 ± 2

16 ± 3

116 ± 8

86 ± 11^*

0.54 ± 0.08

0.55 ± 0.05

aCg

89 ± 12

80 ± 7

75 ± 9

67 ± 7

213 ± 23

201 ± 24

0.79 ± 0.09

0.84 ± 0.08

NAC

1591 ± 266

1544 ± 215

904 ± 136

1036 ± 109

601 ± 112

620 ± 59

0.6 ± 0.05

0.76 ± 0.11

DMS

4107 ± 356

4535 ± 1047

1561 ± 162

1496 ± 195

670 ± 74

723 ± 143

0.36 ± 0.03

0.39 ± 0.04

DLS

6064 ± 666

5028 ± 176

802 ± 92

790 ± 82

500 ± 60

448 ± 20

0.13 ± 0.01

0.15 ± 0.01

6 ± 0.9

8 ± 1

20 ± 1

22 ± 2

72 ± 8

77 ± 6

3.85 ± 0.58

2.67 ± 0.22

240 ± 54

287 ± 48.8

83 ± 19

121 ± 26

150 ± 22.6

215 ± 49

0.33 ± 0.05

0.46 ± 0.09

48 ± 6

44 ± 4

13 ± 1.8

13 ± 2

39 ± 3.78

41.8 ± 5.3

0.3 ± 0.03

0.3 ± 0.02

VTA

215 ± 41

234 ± 38

191 ± 37

207 ± 27

205 ± 30.1

239 ± 18.8

0.88 ± 0.05

0.91 ± 0.06

259 ± 54

223 ± 46

141 ± 15

136 ± 21

265 ± 36

252 ± 40.3

0.64 ± 0.04

0.76 ± 0.04^*

128 ± 19

106 ± 14

105 ± 8

101 ± 13.1

171 ± 18.8

136 ± 16.9

0.98 ± 0.07

0.99 ± 0.08

	DA	DOPAC	HVA	DOPAC/DA
OF	10.8 ± 1.2	11.2 ± 0.96	26 ± 3	25 ± 3	69 ± 10	45 ± 3^*	2.48 ± 0.2	2.36 ± 0.31
PL	41 ± 5	29 ± 4	17 ± 2	16 ± 3	116 ± 8	86 ± 11^*	0.54 ± 0.08	0.55 ± 0.05
aCg	89 ± 12	80 ± 7	75 ± 9	67 ± 7	213 ± 23	201 ± 24	0.79 ± 0.09	0.84 ± 0.08
NAC	1591 ± 266	1544 ± 215	904 ± 136	1036 ± 109	601 ± 112	620 ± 59	0.6 ± 0.05	0.76 ± 0.11
DMS	4107 ± 356	4535 ± 1047	1561 ± 162	1496 ± 195	670 ± 74	723 ± 143	0.36 ± 0.03	0.39 ± 0.04
DLS	6064 ± 666	5028 ± 176	802 ± 92	790 ± 82	500 ± 60	448 ± 20	0.13 ± 0.01	0.15 ± 0.01
Th	6 ± 0.9	8 ± 1	20 ± 1	22 ± 2	72 ± 8	77 ± 6	3.85 ± 0.58	2.67 ± 0.22
AM	240 ± 54	287 ± 48.8	83 ± 19	121 ± 26	150 ± 22.6	215 ± 49	0.33 ± 0.05	0.46 ± 0.09
dH	48 ± 6	44 ± 4	13 ± 1.8	13 ± 2	39 ± 3.78	41.8 ± 5.3	0.3 ± 0.03	0.3 ± 0.02
VTA	215 ± 41	234 ± 38	191 ± 37	207 ± 27	205 ± 30.1	239 ± 18.8	0.88 ± 0.05	0.91 ± 0.06
SN	259 ± 54	223 ± 46	141 ± 15	136 ± 21	265 ± 36	252 ± 40.3	0.64 ± 0.04	0.76 ± 0.04^*
vY	128 ± 19	106 ± 14	105 ± 8	101 ± 13.1	171 ± 18.8	136 ± 16.9	0.98 ± 0.07	0.99 ± 0.08

Table 1

Open in new tab

Tissue content of DA and its metabolites (pg/mg) and the ratio DOPAC/DA in various brain regions of WT and Snord115-KO mice

	DA		DOPAC		HVA		DOPAC/DA
region	WT	SNORD	WT	SNORD	WT	SNORD	WT	SNORD
OF	10.8 ± 1.2	11.2 ± 0.96	26 ± 3	25 ± 3	69 ± 10	45 ± 3^*	2.48 ± 0.2	2.36 ± 0.31
PL	41 ± 5	29 ± 4	17 ± 2	16 ± 3	116 ± 8	86 ± 11^*	0.54 ± 0.08	0.55 ± 0.05
aCg	89 ± 12	80 ± 7	75 ± 9	67 ± 7	213 ± 23	201 ± 24	0.79 ± 0.09	0.84 ± 0.08
NAC	1591 ± 266	1544 ± 215	904 ± 136	1036 ± 109	601 ± 112	620 ± 59	0.6 ± 0.05	0.76 ± 0.11
DMS	4107 ± 356	4535 ± 1047	1561 ± 162	1496 ± 195	670 ± 74	723 ± 143	0.36 ± 0.03	0.39 ± 0.04
DLS	6064 ± 666	5028 ± 176	802 ± 92	790 ± 82	500 ± 60	448 ± 20	0.13 ± 0.01	0.15 ± 0.01
Th	6 ± 0.9	8 ± 1	20 ± 1	22 ± 2	72 ± 8	77 ± 6	3.85 ± 0.58	2.67 ± 0.22
AM	240 ± 54	287 ± 48.8	83 ± 19	121 ± 26	150 ± 22.6	215 ± 49	0.33 ± 0.05	0.46 ± 0.09
dH	48 ± 6	44 ± 4	13 ± 1.8	13 ± 2	39 ± 3.78	41.8 ± 5.3	0.3 ± 0.03	0.3 ± 0.02
VTA	215 ± 41	234 ± 38	191 ± 37	207 ± 27	205 ± 30.1	239 ± 18.8	0.88 ± 0.05	0.91 ± 0.06
SN	259 ± 54	223 ± 46	141 ± 15	136 ± 21	265 ± 36	252 ± 40.3	0.64 ± 0.04	0.76 ± 0.04^*
vY	128 ± 19	106 ± 14	105 ± 8	101 ± 13.1	171 ± 18.8	136 ± 16.9	0.98 ± 0.07	0.99 ± 0.08

	DA		DOPAC		HVA		DOPAC/DA
region	WT	SNORD	WT	SNORD	WT	SNORD	WT	SNORD
OF	10.8 ± 1.2	11.2 ± 0.96	26 ± 3	25 ± 3	69 ± 10	45 ± 3^*	2.48 ± 0.2	2.36 ± 0.31
PL	41 ± 5	29 ± 4	17 ± 2	16 ± 3	116 ± 8	86 ± 11^*	0.54 ± 0.08	0.55 ± 0.05
aCg	89 ± 12	80 ± 7	75 ± 9	67 ± 7	213 ± 23	201 ± 24	0.79 ± 0.09	0.84 ± 0.08
NAC	1591 ± 266	1544 ± 215	904 ± 136	1036 ± 109	601 ± 112	620 ± 59	0.6 ± 0.05	0.76 ± 0.11
DMS	4107 ± 356	4535 ± 1047	1561 ± 162	1496 ± 195	670 ± 74	723 ± 143	0.36 ± 0.03	0.39 ± 0.04
DLS	6064 ± 666	5028 ± 176	802 ± 92	790 ± 82	500 ± 60	448 ± 20	0.13 ± 0.01	0.15 ± 0.01
Th	6 ± 0.9	8 ± 1	20 ± 1	22 ± 2	72 ± 8	77 ± 6	3.85 ± 0.58	2.67 ± 0.22
AM	240 ± 54	287 ± 48.8	83 ± 19	121 ± 26	150 ± 22.6	215 ± 49	0.33 ± 0.05	0.46 ± 0.09
dH	48 ± 6	44 ± 4	13 ± 1.8	13 ± 2	39 ± 3.78	41.8 ± 5.3	0.3 ± 0.03	0.3 ± 0.02
VTA	215 ± 41	234 ± 38	191 ± 37	207 ± 27	205 ± 30.1	239 ± 18.8	0.88 ± 0.05	0.91 ± 0.06
SN	259 ± 54	223 ± 46	141 ± 15	136 ± 21	265 ± 36	252 ± 40.3	0.64 ± 0.04	0.76 ± 0.04^*
vY	128 ± 19	106 ± 14	105 ± 8	101 ± 13.1	171 ± 18.8	136 ± 16.9	0.98 ± 0.07	0.99 ± 0.08

All values are expressed as mean ± SEM (pg/mg of tissue for individual compounds) except the ratio. Significance is indicated as follows: ^*P < 0.05 (Students t-test). (n = 8–10 except in the DL where n = 5 due to an experimental error).

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