Table 2 Open in new tab Tissue content...

	NA	5-HT	5-HIAA	5-HIAA/5-HT
OF	197 ± 12	174 ± 12	161 ± 15	155 ± 12	169 ± 18	140 ± 15	1.11 ± 0.13	0.96 ± 0.13
PL	340 ± 39	306 ± 24	158 ± 14	134 ± 16	108 ± 12	112 ± 14	0.7 ± 0.07	0.85 ± 0.07
aCg	586 ± 58	522 ± 55	78 ± 8	87 ± 10	147 ± 15	141 ± 14	2.34 ± 0.35	1.61 ± 0.17
NAC	130 ± 20	128 ± 15	299 ± 42	298 ± 26	210 ± 34	199 ± 11	0.71 ± 0.06	0.96 ± 0.05
DMS	50 ± 3	65 ± 11	193 ± 13	192 ± 41	120 ± 10	134 ± 26	0.65 ± 0.06	0.76 ± 0.04
DLS	25 ± 2	25 ± 3	156 ± 18	138 ± 6	114 ± 12	96 ± 4	0.75 ± 0.04	0.81 ± 0.05
Th	178 ± 11	199 ± 16	107 ± 10	127 ± 14	290 ± 13	304 ± 22	3.05 ± 0.25	2.38 ± 0.14^*
AM	814 ± 182	451 ± 43	454 ± 38	422 ± 56	297 ± 27	322 ± 19	0.66 ± 0.04	0.74 ± 0.06
dH	239 ± 23	281 ± 23	334 ± 49	381 ± 23	554 ± 65	580 ± 56	1.85 ± 0.2	1.53 ± 0.14
VTA	409 ± 31	369 ± 22	450 ± 30	393 ± 29	529 ± 48	463 ± 34	1.3 ± 0.01	1.21 ± 0.09
SN	259 ± 20	217 ± 22	1068 ± 174	980 ± 128	632 ± 36	541 ± 28	0.7 ± 0.08	0.6 ± 0.04
vY	548 ± 56	646 ± 71	717 ± 61	506 ± 39^*	624 ± 52	488 ± 45	0.89 ± 0.06	0.97 ± 0.05

5-HT

5-HIAA

5-HIAA/5-HT

region

SNORD

197 ± 12

174 ± 12

161 ± 15

155 ± 12

169 ± 18

140 ± 15

1.11 ± 0.13

0.96 ± 0.13

340 ± 39

306 ± 24

158 ± 14

134 ± 16

108 ± 12

112 ± 14

0.7 ± 0.07

0.85 ± 0.07

aCg

586 ± 58

522 ± 55

78 ± 8

87 ± 10

147 ± 15

141 ± 14

2.34 ± 0.35

1.61 ± 0.17

NAC

130 ± 20

128 ± 15

299 ± 42

298 ± 26

210 ± 34

199 ± 11

0.71 ± 0.06

0.96 ± 0.05

DMS

50 ± 3

65 ± 11

193 ± 13

192 ± 41

120 ± 10

134 ± 26

0.65 ± 0.06

0.76 ± 0.04

DLS

25 ± 2

25 ± 3

156 ± 18

138 ± 6

114 ± 12

96 ± 4

0.75 ± 0.04

0.81 ± 0.05

178 ± 11

199 ± 16

107 ± 10

127 ± 14

290 ± 13

304 ± 22

3.05 ± 0.25

2.38 ± 0.14^*

814 ± 182

451 ± 43

454 ± 38

422 ± 56

297 ± 27

322 ± 19

0.66 ± 0.04

0.74 ± 0.06

239 ± 23

281 ± 23

334 ± 49

381 ± 23

554 ± 65

580 ± 56

1.85 ± 0.2

1.53 ± 0.14

VTA

409 ± 31

369 ± 22

450 ± 30

393 ± 29

529 ± 48

463 ± 34

1.3 ± 0.01

1.21 ± 0.09

259 ± 20

217 ± 22

1068 ± 174

980 ± 128

632 ± 36

541 ± 28

0.7 ± 0.08

0.6 ± 0.04

548 ± 56

646 ± 71

717 ± 61

506 ± 39^*

624 ± 52

488 ± 45

0.89 ± 0.06

0.97 ± 0.05

	NA	5-HT	5-HIAA	5-HIAA/5-HT
OF	197 ± 12	174 ± 12	161 ± 15	155 ± 12	169 ± 18	140 ± 15	1.11 ± 0.13	0.96 ± 0.13
PL	340 ± 39	306 ± 24	158 ± 14	134 ± 16	108 ± 12	112 ± 14	0.7 ± 0.07	0.85 ± 0.07
aCg	586 ± 58	522 ± 55	78 ± 8	87 ± 10	147 ± 15	141 ± 14	2.34 ± 0.35	1.61 ± 0.17
NAC	130 ± 20	128 ± 15	299 ± 42	298 ± 26	210 ± 34	199 ± 11	0.71 ± 0.06	0.96 ± 0.05
DMS	50 ± 3	65 ± 11	193 ± 13	192 ± 41	120 ± 10	134 ± 26	0.65 ± 0.06	0.76 ± 0.04
DLS	25 ± 2	25 ± 3	156 ± 18	138 ± 6	114 ± 12	96 ± 4	0.75 ± 0.04	0.81 ± 0.05
Th	178 ± 11	199 ± 16	107 ± 10	127 ± 14	290 ± 13	304 ± 22	3.05 ± 0.25	2.38 ± 0.14^*
AM	814 ± 182	451 ± 43	454 ± 38	422 ± 56	297 ± 27	322 ± 19	0.66 ± 0.04	0.74 ± 0.06
dH	239 ± 23	281 ± 23	334 ± 49	381 ± 23	554 ± 65	580 ± 56	1.85 ± 0.2	1.53 ± 0.14
VTA	409 ± 31	369 ± 22	450 ± 30	393 ± 29	529 ± 48	463 ± 34	1.3 ± 0.01	1.21 ± 0.09
SN	259 ± 20	217 ± 22	1068 ± 174	980 ± 128	632 ± 36	541 ± 28	0.7 ± 0.08	0.6 ± 0.04
vY	548 ± 56	646 ± 71	717 ± 61	506 ± 39^*	624 ± 52	488 ± 45	0.89 ± 0.06	0.97 ± 0.05

Table 2

Open in new tab

Tissue content of NA, 5-HT and its metabolite (pg/mg) and the ratio 5-HIAA/5-HT in various brain regions of WT and Snord115-KO mice

	NA		5-HT		5-HIAA		5-HIAA/5-HT
region	WT	SNORD	WT	SNORD	WT	SNORD	WT	SNORD
OF	197 ± 12	174 ± 12	161 ± 15	155 ± 12	169 ± 18	140 ± 15	1.11 ± 0.13	0.96 ± 0.13
PL	340 ± 39	306 ± 24	158 ± 14	134 ± 16	108 ± 12	112 ± 14	0.7 ± 0.07	0.85 ± 0.07
aCg	586 ± 58	522 ± 55	78 ± 8	87 ± 10	147 ± 15	141 ± 14	2.34 ± 0.35	1.61 ± 0.17
NAC	130 ± 20	128 ± 15	299 ± 42	298 ± 26	210 ± 34	199 ± 11	0.71 ± 0.06	0.96 ± 0.05
DMS	50 ± 3	65 ± 11	193 ± 13	192 ± 41	120 ± 10	134 ± 26	0.65 ± 0.06	0.76 ± 0.04
DLS	25 ± 2	25 ± 3	156 ± 18	138 ± 6	114 ± 12	96 ± 4	0.75 ± 0.04	0.81 ± 0.05
Th	178 ± 11	199 ± 16	107 ± 10	127 ± 14	290 ± 13	304 ± 22	3.05 ± 0.25	2.38 ± 0.14^*
AM	814 ± 182	451 ± 43	454 ± 38	422 ± 56	297 ± 27	322 ± 19	0.66 ± 0.04	0.74 ± 0.06
dH	239 ± 23	281 ± 23	334 ± 49	381 ± 23	554 ± 65	580 ± 56	1.85 ± 0.2	1.53 ± 0.14
VTA	409 ± 31	369 ± 22	450 ± 30	393 ± 29	529 ± 48	463 ± 34	1.3 ± 0.01	1.21 ± 0.09
SN	259 ± 20	217 ± 22	1068 ± 174	980 ± 128	632 ± 36	541 ± 28	0.7 ± 0.08	0.6 ± 0.04
vY	548 ± 56	646 ± 71	717 ± 61	506 ± 39^*	624 ± 52	488 ± 45	0.89 ± 0.06	0.97 ± 0.05

	NA		5-HT		5-HIAA		5-HIAA/5-HT
region	WT	SNORD	WT	SNORD	WT	SNORD	WT	SNORD
OF	197 ± 12	174 ± 12	161 ± 15	155 ± 12	169 ± 18	140 ± 15	1.11 ± 0.13	0.96 ± 0.13
PL	340 ± 39	306 ± 24	158 ± 14	134 ± 16	108 ± 12	112 ± 14	0.7 ± 0.07	0.85 ± 0.07
aCg	586 ± 58	522 ± 55	78 ± 8	87 ± 10	147 ± 15	141 ± 14	2.34 ± 0.35	1.61 ± 0.17
NAC	130 ± 20	128 ± 15	299 ± 42	298 ± 26	210 ± 34	199 ± 11	0.71 ± 0.06	0.96 ± 0.05
DMS	50 ± 3	65 ± 11	193 ± 13	192 ± 41	120 ± 10	134 ± 26	0.65 ± 0.06	0.76 ± 0.04
DLS	25 ± 2	25 ± 3	156 ± 18	138 ± 6	114 ± 12	96 ± 4	0.75 ± 0.04	0.81 ± 0.05
Th	178 ± 11	199 ± 16	107 ± 10	127 ± 14	290 ± 13	304 ± 22	3.05 ± 0.25	2.38 ± 0.14^*
AM	814 ± 182	451 ± 43	454 ± 38	422 ± 56	297 ± 27	322 ± 19	0.66 ± 0.04	0.74 ± 0.06
dH	239 ± 23	281 ± 23	334 ± 49	381 ± 23	554 ± 65	580 ± 56	1.85 ± 0.2	1.53 ± 0.14
VTA	409 ± 31	369 ± 22	450 ± 30	393 ± 29	529 ± 48	463 ± 34	1.3 ± 0.01	1.21 ± 0.09
SN	259 ± 20	217 ± 22	1068 ± 174	980 ± 128	632 ± 36	541 ± 28	0.7 ± 0.08	0.6 ± 0.04
vY	548 ± 56	646 ± 71	717 ± 61	506 ± 39^*	624 ± 52	488 ± 45	0.89 ± 0.06	0.97 ± 0.05

All values are expressed as mean ± SEM (pg/mg of tissue for individual compounds) except the ratio. Significance is indicated as follows: ^*P < 0.05 (Students t-test). (n = 8–10 except in the DL where n = 5 due to an experimental error).

This Feature Is Available To Subscribers Only