Table 6. Open in new tab Impact of...

Predictor

OR (95% CI)

Unadjusted P

Adjusted OR^a (95% CI)

Adjusted P

IL-13R

0.087

0.143

Weak staining

0.78 (0.22-2.77)

0.29 (0.02-3.51)

Moderate staining

0.12 (0.01-1.12)

1.36 (0.12-15.38)

Strong staining

0.11 (0.01-1.02)

0.05 (0.01-0.95)

IL-13R (strong staining vs not)

0.17 (0.02-1.43)

0.103

0.06 (0.01-0.92)

0.044

IL-13R (moderate or strong staining vs not)

0.13 (0.03-0.63)

0.011

0.46 (0.09-2.47)

0.367

HLA-DR

0.255

0.715

Weak staining

0.48 (0.12-1.81)

1.55 (0.20-12.17)

Moderate staining

0.33 (0.07-1.54)

0.49 (0.05-4.99)

Strong staining

0.15 (0.01-1.39)

N/A

HLA-DR (strong staining vs not)

0.25 (0.03-2.12)

0.203

N/A

HLA-DR (moderate or strong staining vs not)

0.35 (0.10-1.24)

0.104

0.23 (0.03-1.95)

0.177

HLA-DR (percentage of cells staining)

0.85 (0.75-0.97)

0.012

0.89 (0.78-1.03)

0.120

HLA-DR (≥20% staining vs less)

0.27 (0.07-1.06)

0.061

0.49 (0.08-3.09)

0.451

HLA-DR (≥15% staining vs less)

0.34 (0.11-1.06)

0.064

0.44 (0.09-2.20)

0.320

MPO (percentage of cells staining, continuous)

0.93 (0.86-0.99)

0.046

0.92 (0.83-1.03)

0.162

MPO (≥10% staining vs less)

0.40 (0.13-1.26)

0.118

0.44 (0.07-2.61)

0.363

MPO (≥20% staining vs less)

0.11 (0.01-0.94)

0.043

0.06 (0.01-2.11)

0.123

Tenascin

0.247

0.269

Weak staining

0.33 (0.09-1.21)

0.24 (0.02-3.02)

Moderate staining

0.70 (0.15-3.29)

N/A

Strong staining

N/A

Tenascin (moderate/strong vs not)

0.84 (0.20-3.55)

0.818

N/A

TNF-α(percentage of cells staining, continuous)

0.87 (0.76-1.00)

0.051

0.98 (0.84-1.14)

0.799

TNF-α (≥5% staining vs less)

0.81 (0.26-2.49)

0.715

0.86 (0.16-4.59)

0.855

TNF-α (≥10% staining vs less)

0.32 (0.08-1.27)

0.106

0.87 (0.16-4.74)

0.868

Table 6.

Open in new tab

Impact of baseline immunohistochemistry analysis of ileum biopsies on achieving endoscopic remission in the ileum (segment SES-CD of 0).

Predictor	OR (95% CI)	Unadjusted P	Adjusted OR^a (95% CI)	Adjusted P
IL-13R		0.087		0.143
Weak staining	0.78 (0.22-2.77)		0.29 (0.02-3.51)
Moderate staining	0.12 (0.01-1.12)		1.36 (0.12-15.38)
Strong staining	0.11 (0.01-1.02)		0.05 (0.01-0.95)
IL-13R (strong staining vs not)	0.17 (0.02-1.43)	0.103	0.06 (0.01-0.92)	0.044
IL-13R (moderate or strong staining vs not)	0.13 (0.03-0.63)	0.011	0.46 (0.09-2.47)	0.367
HLA-DR		0.255		0.715
Weak staining	0.48 (0.12-1.81)		1.55 (0.20-12.17)
Moderate staining	0.33 (0.07-1.54)		0.49 (0.05-4.99)
Strong staining	0.15 (0.01-1.39)		N/A
HLA-DR (strong staining vs not)	0.25 (0.03-2.12)	0.203	N/A	N/A
HLA-DR (moderate or strong staining vs not)	0.35 (0.10-1.24)	0.104	0.23 (0.03-1.95)	0.177
HLA-DR (percentage of cells staining)	0.85 (0.75-0.97)	0.012	0.89 (0.78-1.03)	0.120
HLA-DR (≥20% staining vs less)	0.27 (0.07-1.06)	0.061	0.49 (0.08-3.09)	0.451
HLA-DR (≥15% staining vs less)	0.34 (0.11-1.06)	0.064	0.44 (0.09-2.20)	0.320
MPO (percentage of cells staining, continuous)	0.93 (0.86-0.99)	0.046	0.92 (0.83-1.03)	0.162
MPO (≥10% staining vs less)	0.40 (0.13-1.26)	0.118	0.44 (0.07-2.61)	0.363
MPO (≥20% staining vs less)	0.11 (0.01-0.94)	0.043	0.06 (0.01-2.11)	0.123
Tenascin		0.247		0.269
Weak staining	0.33 (0.09-1.21)		0.24 (0.02-3.02)
Moderate staining	0.70 (0.15-3.29)		N/A
Strong staining	N/A		N/A
Tenascin (moderate/strong vs not)	0.84 (0.20-3.55)	0.818	N/A	N/A
TNF-α(percentage of cells staining, continuous)	0.87 (0.76-1.00)	0.051	0.98 (0.84-1.14)	0.799
TNF-α (≥5% staining vs less)	0.81 (0.26-2.49)	0.715	0.86 (0.16-4.59)	0.855
TNF-α (≥10% staining vs less)	0.32 (0.08-1.27)	0.106	0.87 (0.16-4.74)	0.868

Predictor	OR (95% CI)	Unadjusted P	Adjusted OR^a (95% CI)	Adjusted P
IL-13R		0.087		0.143
Weak staining	0.78 (0.22-2.77)		0.29 (0.02-3.51)
Moderate staining	0.12 (0.01-1.12)		1.36 (0.12-15.38)
Strong staining	0.11 (0.01-1.02)		0.05 (0.01-0.95)
IL-13R (strong staining vs not)	0.17 (0.02-1.43)	0.103	0.06 (0.01-0.92)	0.044
IL-13R (moderate or strong staining vs not)	0.13 (0.03-0.63)	0.011	0.46 (0.09-2.47)	0.367
HLA-DR		0.255		0.715
Weak staining	0.48 (0.12-1.81)		1.55 (0.20-12.17)
Moderate staining	0.33 (0.07-1.54)		0.49 (0.05-4.99)
Strong staining	0.15 (0.01-1.39)		N/A
HLA-DR (strong staining vs not)	0.25 (0.03-2.12)	0.203	N/A	N/A
HLA-DR (moderate or strong staining vs not)	0.35 (0.10-1.24)	0.104	0.23 (0.03-1.95)	0.177
HLA-DR (percentage of cells staining)	0.85 (0.75-0.97)	0.012	0.89 (0.78-1.03)	0.120
HLA-DR (≥20% staining vs less)	0.27 (0.07-1.06)	0.061	0.49 (0.08-3.09)	0.451
HLA-DR (≥15% staining vs less)	0.34 (0.11-1.06)	0.064	0.44 (0.09-2.20)	0.320
MPO (percentage of cells staining, continuous)	0.93 (0.86-0.99)	0.046	0.92 (0.83-1.03)	0.162
MPO (≥10% staining vs less)	0.40 (0.13-1.26)	0.118	0.44 (0.07-2.61)	0.363
MPO (≥20% staining vs less)	0.11 (0.01-0.94)	0.043	0.06 (0.01-2.11)	0.123
Tenascin		0.247		0.269
Weak staining	0.33 (0.09-1.21)		0.24 (0.02-3.02)
Moderate staining	0.70 (0.15-3.29)		N/A
Strong staining	N/A		N/A
Tenascin (moderate/strong vs not)	0.84 (0.20-3.55)	0.818	N/A	N/A
TNF-α(percentage of cells staining, continuous)	0.87 (0.76-1.00)	0.051	0.98 (0.84-1.14)	0.799
TNF-α (≥5% staining vs less)	0.81 (0.26-2.49)	0.715	0.86 (0.16-4.59)	0.855
TNF-α (≥10% staining vs less)	0.32 (0.08-1.27)	0.106	0.87 (0.16-4.74)	0.868

^aAdjusted for arm, prior anti-TNF-α exposure, baseline ileal SES-CD score, baseline ileal ulcer size, and disease duration.

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