Sensitivity and specificity of ex vivo CM using Histolog Scanner compared to histologic analysis on paraffin-embedded or frozen (Mohs) H&E sections
| . | n . | True positive . | False positive . | True negative . | False negative . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|
| Biopsies | 16 | 13 | 0 | 2 | 1 | 93 (CI: 66.1%–99.8%) | 100 (CI: 15.8%–100%) |
| Tumour type | |||||||
| BCC | 10 | 9 | 0 | 1 | 0 | 100 (CI: 66.4%–100%) | 100 (CI: 2.5%–100%) |
| SCC | 6 | 4 | 0 | 1 | 1 | 80 (CI: 28.4%–99.4%) | 100 (CI: 2.5%–100%) |
| Surgical margins | 93 | 8 | 4 | 76 | 5 | 61.5 (CI: 31.6–86.1) | 95 (CI: 87.7–98.6) |
| Tumour type | |||||||
| BCC | 42 | 4 | 0 | 37 | 1 | 80 (CI: 28.4–99.4) | 100 (CI: 90.6–100) |
| SCC (including BSC) | 51 | 4 | 4 | 39 | 4 | 50 (CI: 15.7–84.3) | 91 (CI: 77.9–97.4) |
| Surgical specimen type | |||||||
| Depth | 39 | 1 | 2 | 35 | 1 | 50 (CI: 1.3–98.8) | 95 (CI: 81.8–99.3) |
| Periphery | 30 | 2 | 2 | 24 | 2 | 50 (CI: 6.8–93.2) | 92 (CI: 74.9–99) |
| Mohs | 24 | 5 | 0 | 17 | 2 | 71 (CI: 29–96.3) | 100 (CI: 80.5–100) |
| . | n . | True positive . | False positive . | True negative . | False negative . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|
| Biopsies | 16 | 13 | 0 | 2 | 1 | 93 (CI: 66.1%–99.8%) | 100 (CI: 15.8%–100%) |
| Tumour type | |||||||
| BCC | 10 | 9 | 0 | 1 | 0 | 100 (CI: 66.4%–100%) | 100 (CI: 2.5%–100%) |
| SCC | 6 | 4 | 0 | 1 | 1 | 80 (CI: 28.4%–99.4%) | 100 (CI: 2.5%–100%) |
| Surgical margins | 93 | 8 | 4 | 76 | 5 | 61.5 (CI: 31.6–86.1) | 95 (CI: 87.7–98.6) |
| Tumour type | |||||||
| BCC | 42 | 4 | 0 | 37 | 1 | 80 (CI: 28.4–99.4) | 100 (CI: 90.6–100) |
| SCC (including BSC) | 51 | 4 | 4 | 39 | 4 | 50 (CI: 15.7–84.3) | 91 (CI: 77.9–97.4) |
| Surgical specimen type | |||||||
| Depth | 39 | 1 | 2 | 35 | 1 | 50 (CI: 1.3–98.8) | 95 (CI: 81.8–99.3) |
| Periphery | 30 | 2 | 2 | 24 | 2 | 50 (CI: 6.8–93.2) | 92 (CI: 74.9–99) |
| Mohs | 24 | 5 | 0 | 17 | 2 | 71 (CI: 29–96.3) | 100 (CI: 80.5–100) |
Abbreviation: CI, 95% confidence intervals.
Sensitivity and specificity of ex vivo CM using Histolog Scanner compared to histologic analysis on paraffin-embedded or frozen (Mohs) H&E sections
| . | n . | True positive . | False positive . | True negative . | False negative . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|
| Biopsies | 16 | 13 | 0 | 2 | 1 | 93 (CI: 66.1%–99.8%) | 100 (CI: 15.8%–100%) |
| Tumour type | |||||||
| BCC | 10 | 9 | 0 | 1 | 0 | 100 (CI: 66.4%–100%) | 100 (CI: 2.5%–100%) |
| SCC | 6 | 4 | 0 | 1 | 1 | 80 (CI: 28.4%–99.4%) | 100 (CI: 2.5%–100%) |
| Surgical margins | 93 | 8 | 4 | 76 | 5 | 61.5 (CI: 31.6–86.1) | 95 (CI: 87.7–98.6) |
| Tumour type | |||||||
| BCC | 42 | 4 | 0 | 37 | 1 | 80 (CI: 28.4–99.4) | 100 (CI: 90.6–100) |
| SCC (including BSC) | 51 | 4 | 4 | 39 | 4 | 50 (CI: 15.7–84.3) | 91 (CI: 77.9–97.4) |
| Surgical specimen type | |||||||
| Depth | 39 | 1 | 2 | 35 | 1 | 50 (CI: 1.3–98.8) | 95 (CI: 81.8–99.3) |
| Periphery | 30 | 2 | 2 | 24 | 2 | 50 (CI: 6.8–93.2) | 92 (CI: 74.9–99) |
| Mohs | 24 | 5 | 0 | 17 | 2 | 71 (CI: 29–96.3) | 100 (CI: 80.5–100) |
| . | n . | True positive . | False positive . | True negative . | False negative . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|
| Biopsies | 16 | 13 | 0 | 2 | 1 | 93 (CI: 66.1%–99.8%) | 100 (CI: 15.8%–100%) |
| Tumour type | |||||||
| BCC | 10 | 9 | 0 | 1 | 0 | 100 (CI: 66.4%–100%) | 100 (CI: 2.5%–100%) |
| SCC | 6 | 4 | 0 | 1 | 1 | 80 (CI: 28.4%–99.4%) | 100 (CI: 2.5%–100%) |
| Surgical margins | 93 | 8 | 4 | 76 | 5 | 61.5 (CI: 31.6–86.1) | 95 (CI: 87.7–98.6) |
| Tumour type | |||||||
| BCC | 42 | 4 | 0 | 37 | 1 | 80 (CI: 28.4–99.4) | 100 (CI: 90.6–100) |
| SCC (including BSC) | 51 | 4 | 4 | 39 | 4 | 50 (CI: 15.7–84.3) | 91 (CI: 77.9–97.4) |
| Surgical specimen type | |||||||
| Depth | 39 | 1 | 2 | 35 | 1 | 50 (CI: 1.3–98.8) | 95 (CI: 81.8–99.3) |
| Periphery | 30 | 2 | 2 | 24 | 2 | 50 (CI: 6.8–93.2) | 92 (CI: 74.9–99) |
| Mohs | 24 | 5 | 0 | 17 | 2 | 71 (CI: 29–96.3) | 100 (CI: 80.5–100) |
Abbreviation: CI, 95% confidence intervals.
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