No‐observed‐effect concentrations (NOECs), lowest‐observed‐effect concentrations (LOECs), and median effect/lethal concentration (EC50/LC50) estimates for freshwater crustaceans exposed to thiamethoxama
| Organism | Common name | Study ID | Test type | NOEC/LOEC (mg/L) | EC50 (mg/L; 95% CL) | LC50 (mg/L; 95% CL) |
| Acute studies | ||||||
| Asellus aquaticus | Water louse | 11 | 48 h (static) | — | 0.084 (0.044–0.16) | 2.3 (0.82–7.32) |
| 12 | — | >0.32 (ne) | — | |||
| Copepoda | N/A | 11 | 48 h (static) | — | >100 (ne) | >100 (ne) |
| Daphnia magna | Water flea | 7 | 24 h (static) | — | >100 | |
| 48 h (static) | NOEC = 32 | >100 | — | |||
| Daphnia pulex | Water flea | 9 | 24 h (static) | — | >100 (ne) | — |
| Gammarus sp. | N/A | 8 | 24 h (static) | — | 15 (10– 23) | — |
| 48 h (static) | — | 2.8 (1.7–4.1) | — | |||
| Ostracoda | Seed shrimp | 10 | 24 h (static) | — | 0.24 (0.20–0.29) | — |
| 48 h (static) | — | 0.18 (0.15–0.22) | — | |||
| Thamnocephalus platyurus | Fairy shrimp | 9 | 24 h (static) | — | >100 (ne) | — |
| Procambarus clarkii | Crayfish | 6 | 24 h (static renewal) | — | 3.7 (2.7–5.1) | 110 (13–ne)c |
| 48 h (static renewal) | — | 3.0 (2.1–4.6) | 17 (6.0–14 000)c | |||
| 72 h (static renewal) | — | 2.8 (2.0–3.9) | 12 (4.9–580)c | |||
| 96 h (static renewal) | NOEC = 0.65 | 2.3 (1.6–3.2) | 10 (4.5–360)c | |||
| Chronic studies | ||||||
| Daphnia magna (parent and juvenile) | Water flea | 15 | 14 d (semi‐static) | Reproduction (no. of young/female): NOEC = 100b; LOEC = >100 | — | — |
| 21 d (semi‐static) | Reproduction (no. of young/female); adult length; time to first brood: NOEC = 100b; LOEC = >100 | Reproduction (no. of young/female); immobilization: >100b | — |
| Organism | Common name | Study ID | Test type | NOEC/LOEC (mg/L) | EC50 (mg/L; 95% CL) | LC50 (mg/L; 95% CL) |
| Acute studies | ||||||
| Asellus aquaticus | Water louse | 11 | 48 h (static) | — | 0.084 (0.044–0.16) | 2.3 (0.82–7.32) |
| 12 | — | >0.32 (ne) | — | |||
| Copepoda | N/A | 11 | 48 h (static) | — | >100 (ne) | >100 (ne) |
| Daphnia magna | Water flea | 7 | 24 h (static) | — | >100 | |
| 48 h (static) | NOEC = 32 | >100 | — | |||
| Daphnia pulex | Water flea | 9 | 24 h (static) | — | >100 (ne) | — |
| Gammarus sp. | N/A | 8 | 24 h (static) | — | 15 (10– 23) | — |
| 48 h (static) | — | 2.8 (1.7–4.1) | — | |||
| Ostracoda | Seed shrimp | 10 | 24 h (static) | — | 0.24 (0.20–0.29) | — |
| 48 h (static) | — | 0.18 (0.15–0.22) | — | |||
| Thamnocephalus platyurus | Fairy shrimp | 9 | 24 h (static) | — | >100 (ne) | — |
| Procambarus clarkii | Crayfish | 6 | 24 h (static renewal) | — | 3.7 (2.7–5.1) | 110 (13–ne)c |
| 48 h (static renewal) | — | 3.0 (2.1–4.6) | 17 (6.0–14 000)c | |||
| 72 h (static renewal) | — | 2.8 (2.0–3.9) | 12 (4.9–580)c | |||
| 96 h (static renewal) | NOEC = 0.65 | 2.3 (1.6–3.2) | 10 (4.5–360)c | |||
| Chronic studies | ||||||
| Daphnia magna (parent and juvenile) | Water flea | 15 | 14 d (semi‐static) | Reproduction (no. of young/female): NOEC = 100b; LOEC = >100 | — | — |
| 21 d (semi‐static) | Reproduction (no. of young/female); adult length; time to first brood: NOEC = 100b; LOEC = >100 | Reproduction (no. of young/female); immobilization: >100b | — |
The endpoint for all NOEC and EC50 values is immobilization, except for study 6 (NOEC for immobility and mortality combined); study 12 (immobilization and mortality combined), and study 15 (as indicated). The LOEC endpoints are as indicated.
Greatest tested concentration.
LC50 calculated by probit analysis, but response considered insufficient (max. 50% mortality) to produce adequate effect estimate.
ne = not estimable; N/A = not applicable.
No‐observed‐effect concentrations (NOECs), lowest‐observed‐effect concentrations (LOECs), and median effect/lethal concentration (EC50/LC50) estimates for freshwater crustaceans exposed to thiamethoxama
| Organism | Common name | Study ID | Test type | NOEC/LOEC (mg/L) | EC50 (mg/L; 95% CL) | LC50 (mg/L; 95% CL) |
| Acute studies | ||||||
| Asellus aquaticus | Water louse | 11 | 48 h (static) | — | 0.084 (0.044–0.16) | 2.3 (0.82–7.32) |
| 12 | — | >0.32 (ne) | — | |||
| Copepoda | N/A | 11 | 48 h (static) | — | >100 (ne) | >100 (ne) |
| Daphnia magna | Water flea | 7 | 24 h (static) | — | >100 | |
| 48 h (static) | NOEC = 32 | >100 | — | |||
| Daphnia pulex | Water flea | 9 | 24 h (static) | — | >100 (ne) | — |
| Gammarus sp. | N/A | 8 | 24 h (static) | — | 15 (10– 23) | — |
| 48 h (static) | — | 2.8 (1.7–4.1) | — | |||
| Ostracoda | Seed shrimp | 10 | 24 h (static) | — | 0.24 (0.20–0.29) | — |
| 48 h (static) | — | 0.18 (0.15–0.22) | — | |||
| Thamnocephalus platyurus | Fairy shrimp | 9 | 24 h (static) | — | >100 (ne) | — |
| Procambarus clarkii | Crayfish | 6 | 24 h (static renewal) | — | 3.7 (2.7–5.1) | 110 (13–ne)c |
| 48 h (static renewal) | — | 3.0 (2.1–4.6) | 17 (6.0–14 000)c | |||
| 72 h (static renewal) | — | 2.8 (2.0–3.9) | 12 (4.9–580)c | |||
| 96 h (static renewal) | NOEC = 0.65 | 2.3 (1.6–3.2) | 10 (4.5–360)c | |||
| Chronic studies | ||||||
| Daphnia magna (parent and juvenile) | Water flea | 15 | 14 d (semi‐static) | Reproduction (no. of young/female): NOEC = 100b; LOEC = >100 | — | — |
| 21 d (semi‐static) | Reproduction (no. of young/female); adult length; time to first brood: NOEC = 100b; LOEC = >100 | Reproduction (no. of young/female); immobilization: >100b | — |
| Organism | Common name | Study ID | Test type | NOEC/LOEC (mg/L) | EC50 (mg/L; 95% CL) | LC50 (mg/L; 95% CL) |
| Acute studies | ||||||
| Asellus aquaticus | Water louse | 11 | 48 h (static) | — | 0.084 (0.044–0.16) | 2.3 (0.82–7.32) |
| 12 | — | >0.32 (ne) | — | |||
| Copepoda | N/A | 11 | 48 h (static) | — | >100 (ne) | >100 (ne) |
| Daphnia magna | Water flea | 7 | 24 h (static) | — | >100 | |
| 48 h (static) | NOEC = 32 | >100 | — | |||
| Daphnia pulex | Water flea | 9 | 24 h (static) | — | >100 (ne) | — |
| Gammarus sp. | N/A | 8 | 24 h (static) | — | 15 (10– 23) | — |
| 48 h (static) | — | 2.8 (1.7–4.1) | — | |||
| Ostracoda | Seed shrimp | 10 | 24 h (static) | — | 0.24 (0.20–0.29) | — |
| 48 h (static) | — | 0.18 (0.15–0.22) | — | |||
| Thamnocephalus platyurus | Fairy shrimp | 9 | 24 h (static) | — | >100 (ne) | — |
| Procambarus clarkii | Crayfish | 6 | 24 h (static renewal) | — | 3.7 (2.7–5.1) | 110 (13–ne)c |
| 48 h (static renewal) | — | 3.0 (2.1–4.6) | 17 (6.0–14 000)c | |||
| 72 h (static renewal) | — | 2.8 (2.0–3.9) | 12 (4.9–580)c | |||
| 96 h (static renewal) | NOEC = 0.65 | 2.3 (1.6–3.2) | 10 (4.5–360)c | |||
| Chronic studies | ||||||
| Daphnia magna (parent and juvenile) | Water flea | 15 | 14 d (semi‐static) | Reproduction (no. of young/female): NOEC = 100b; LOEC = >100 | — | — |
| 21 d (semi‐static) | Reproduction (no. of young/female); adult length; time to first brood: NOEC = 100b; LOEC = >100 | Reproduction (no. of young/female); immobilization: >100b | — |
The endpoint for all NOEC and EC50 values is immobilization, except for study 6 (NOEC for immobility and mortality combined); study 12 (immobilization and mortality combined), and study 15 (as indicated). The LOEC endpoints are as indicated.
Greatest tested concentration.
LC50 calculated by probit analysis, but response considered insufficient (max. 50% mortality) to produce adequate effect estimate.
ne = not estimable; N/A = not applicable.
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