Table 2 Open in new tab Volumetric...

Pick’s disease

MAPT mutations

Corticobasal degeneration

TDP-A

TDP-C

FUS-atypical FTLDU

No. of cases

Disease duration at scan, mean (SD) (years)

4.7 (1.7)

5.1 (2.4)

4.4 (0.8)

3.8 (2.0)

4.6 (2.4)

3.6 (2.9)

Total brain volume (% control mean)

88 (10)*

94 (9)

85 (6)*

86 (10)*

94 (8)*

89 (4)*

Cerebral asymmetry index^a

4.3 (2.4)*

1.2 (0.8)*

1.3 (0.5)*

3.4 (2.7)*

3.0 (1.0)*

1.6 (0.7)*

Grey matter lobar volume (% control mean)

Frontal

73 (14)*

92 (10)

81 (14)*

73 (11)*

95 (12)

69 (6)*

Temporal

73 (11)*

73 (7)*

87 (17)

76 (15)*

69 (11)*

81 (5)*

Parietal

88 (10)*

89 (11)*

85 (20)

82 (10)*

94 (14)

88 (11)*

Cingulate

70 (15)*

88 (18)*

82 (11)*

65 (7)*

89 (18)*

75 (16)*

Subcortical volumes (% control mean)

Hippocampus

67 (18)*

57 (3)*

86 (16)

77 (27)*

67 (17)*

69 (3)*

Amygdala

55 (21)*

50 (11)*

80 (19)*

75 (23)*

53 (16)*

63 (3)*

Caudate

77 (12)*

87 (12)*

85 (6)*

86 (18)

89 (11)*

66 (19)*

Putamen

62 (12)*

75 (9)*

76 (11)*

75 (9)*

81 (12)*

67 (17)*

Brainstem

97 (11)

95 (10)

91 (13)

94 (11)

99 (7)

92 (19)

Table 2

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Volumetric imaging data for different pathological groups in FTLD cohort

	Pick’s disease	MAPT mutations	Corticobasal degeneration	TDP-A	TDP-C	FUS-atypical FTLDU
No. of cases	9	6	5	7	12	2
Disease duration at scan, mean (SD) (years)	4.7 (1.7)	5.1 (2.4)	4.4 (0.8)	3.8 (2.0)	4.6 (2.4)	3.6 (2.9)
Total brain volume (% control mean)	88 (10)*	94 (9)	85 (6)*	86 (10)*	94 (8)*	89 (4)*
Cerebral asymmetry index^a	4.3 (2.4)*	1.2 (0.8)*	1.3 (0.5)*	3.4 (2.7)*	3.0 (1.0)*	1.6 (0.7)*
Grey matter lobar volume (% control mean)
Frontal	73 (14)*	92 (10)	81 (14)*	73 (11)*	95 (12)	69 (6)*
Temporal	73 (11)*	73 (7)*	87 (17)	76 (15)*	69 (11)*	81 (5)*
Parietal	88 (10)*	89 (11)*	85 (20)	82 (10)*	94 (14)	88 (11)*
Cingulate	70 (15)*	88 (18)*	82 (11)*	65 (7)*	89 (18)*	75 (16)*
Subcortical volumes (% control mean)
Hippocampus	67 (18)*	57 (3)*	86 (16)	77 (27)*	67 (17)*	69 (3)*
Amygdala	55 (21)*	50 (11)*	80 (19)*	75 (23)*	53 (16)*	63 (3)*
Caudate	77 (12)*	87 (12)*	85 (6)*	86 (18)	89 (11)*	66 (19)*
Putamen	62 (12)*	75 (9)*	76 (11)*	75 (9)*	81 (12)*	67 (17)*
Brainstem	97 (11)	95 (10)	91 (13)	94 (11)	99 (7)	92 (19)

	Pick’s disease	MAPT mutations	Corticobasal degeneration	TDP-A	TDP-C	FUS-atypical FTLDU
No. of cases	9	6	5	7	12	2
Disease duration at scan, mean (SD) (years)	4.7 (1.7)	5.1 (2.4)	4.4 (0.8)	3.8 (2.0)	4.6 (2.4)	3.6 (2.9)
Total brain volume (% control mean)	88 (10)*	94 (9)	85 (6)*	86 (10)*	94 (8)*	89 (4)*
Cerebral asymmetry index^a	4.3 (2.4)*	1.2 (0.8)*	1.3 (0.5)*	3.4 (2.7)*	3.0 (1.0)*	1.6 (0.7)*
Grey matter lobar volume (% control mean)
Frontal	73 (14)*	92 (10)	81 (14)*	73 (11)*	95 (12)	69 (6)*
Temporal	73 (11)*	73 (7)*	87 (17)	76 (15)*	69 (11)*	81 (5)*
Parietal	88 (10)*	89 (11)*	85 (20)	82 (10)*	94 (14)	88 (11)*
Cingulate	70 (15)*	88 (18)*	82 (11)*	65 (7)*	89 (18)*	75 (16)*
Subcortical volumes (% control mean)
Hippocampus	67 (18)*	57 (3)*	86 (16)	77 (27)*	67 (17)*	69 (3)*
Amygdala	55 (21)*	50 (11)*	80 (19)*	75 (23)*	53 (16)*	63 (3)*
Caudate	77 (12)*	87 (12)*	85 (6)*	86 (18)	89 (11)*	66 (19)*
Putamen	62 (12)*	75 (9)*	76 (11)*	75 (9)*	81 (12)*	67 (17)*
Brainstem	97 (11)	95 (10)	91 (13)	94 (11)	99 (7)	92 (19)

Only a single FUS-neuronal intermediate filament inclusion disease case was identified and so was not included in the table.

a Calculated as follows: (absolute hemispheric volume difference/whole brain volume × 100).

*Significantly different to controls, P < 0.05; significant volume differences between disease groups (P < 0.05) follow.

Total brain volume: corticobasal degeneration < TDP-C. Asymmetry index: Pick’s disease > MAPT mutations, corticobasal degeneration, TDP-C, FUS-atypical FTLD-U; TDP-A > MAPT mutations, corticobasal degeneration; TDP-C > MAPT mutations, corticobasal degeneration, FUS-atypical FTLD-U. Frontal lobe: Pick’s disease < MAPT mutations, TDP-C; TDP-A < MAPT mutations, TDP-C; FUS-atypical FTLD-U < MAPT mutations, TDP-C. Temporal lobe: TDP-C < corticobasal degeneration, FUS-atypical FTLD-U. Parietal lobe: TDP-A < TDP-C. Cingulate: Pick’s disease < TDP-C; TDP-A < MAPT mutations, corticobasal degeneration, TDP-C. Hippocampus: Pick’s disease < corticobasal degeneration; MAPT mutations < corticobasal degeneration, TDP-C; TDP-C < corticobasal degeneration. Amygdala: Pick’s disease < corticobasal degeneration; MAPT mutations < corticobasal degeneration; TDP-C < corticobasal degeneration. Caudate: Pick’s disease < TDP-C; FUS-atypical FTLD-U < TDP-C. Putamen: Pick’s disease < MAPT mutations, corticobasal degeneration, TDP-A, TDP-C.

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